Therapeutic targeting of pattern-recognition receptors

International Immunopharmacology
Nima Rezaei

Abstract

Innate immune system could recognize the pathogen-associated molecular patterns by pattern-recognition receptors like Toll-like receptor (TLR) and nucleotide-binding oligomerisation domain (NOD) protein. Information regarding the structure and signalling pathways of TLRs and NODs could provide opportunities for new therapeutic approaches to modulate the innate immunity. Therapeutic targeting could be done by prevention of ligand binding to leucine-rich repeats domains of receptors, blocking the interactions between receptors (like Toll/interleukin-1 receptor domains of TLRs) and adaptors in signalling pathways, blocking the enzymes in signalling pathways, and immunostimulation with vaccine adjuvants. These therapeutic approaches could be useful in the treatment of different human diseases like immunological disorders, infections, and cancers. Further research on these receptors and their signalling pathways could help scientists to identify new candidates for therapeutic targeting.

References

Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I SabroeS K Dower
Oct 2, 2002·Immunity·Sean DoyleGenhong Cheng
Dec 20, 2002·Nature·Jonathan Cohen
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
Jan 16, 2003·Immunology Letters·Shizuo Akira, Hiroaki Hemmi
May 27, 2003·Nature Reviews. Immunology·Naohiro Inohara, Gabriel Nuñez
Jun 18, 2003·European Journal of Immunology·David M Underhill
Jul 23, 2003·Current Medicinal Chemistry·Zi-Hua Jiang, R Rao Koganty
Jul 23, 2003·The Journal of Biological Chemistry·Stephen E GirardinDominique Mengin-Lecreulx
Aug 6, 2003·Expert Review of Vaccines·Jay T EvansJory R Baldridge
Aug 7, 2003·Current Opinion in Pharmacology·Luke A J O'Neill
Aug 20, 2003·Cellular Microbiology·Mathias ChamaillardDana J Philpott
Sep 10, 2003·Journal of Leukocyte Biology·B BeutlerR J Ulevitch
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Iftikhar Hussain, Joel N Kline
Nov 7, 2003·Nature·Jules A Hoffmann
Nov 15, 2003·Journal of Clinical Pharmacology·Earvin LiangClifford DiLea
Dec 31, 2003·Molecular Immunology·Masahiro YamamotoShizuo Akira
Mar 27, 2004·The EMBO Journal·Tsuyoshi TanabeGabriel Núñez
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Jul 2, 2004·Nature Reviews. Immunology·Richard J Ulevitch
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Marianna KulkaDean D Metcalfe
Jul 23, 2004·Expert Opinion on Biological Therapy·Jory R BaldridgeDavid Persing
Jul 28, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ulrich R Hengge, Thomas Ruzicka
Sep 30, 2004·Nature Immunology·Kasper HoebeBruce Beutler
Nov 9, 2004·Trends in Immunology·Luke A J O'Neill
Feb 3, 2005·The Journal of Infectious Diseases·Evelyn A Kurt-JonesRobert W Finberg
Apr 7, 2005·Nature Medicine·Achal PashineJeffrey B Ulmer
Apr 23, 2005·Infection and Immunity·Christopher W CluffDavid H Persing
Jul 22, 2005·Clinical Science·Nazia ChaudhuriIan Sabroe
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Michael F Tosi
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Prashant S PatoleHans-Joachim Anders
Oct 6, 2005·Journal of Leukocyte Biology·Bruce S ThompsonThomas C Mitchell

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Citations

Sep 19, 2007·Journal of Industrial Microbiology & Biotechnology·Okom Nkili F C Ofodile
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jan ZeromskiMariusz Kaczmarek
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ralf R Schumann
Sep 21, 2013·Critical Reviews in Oncology/hematology·Sara HarsiniNima Rezaei
Sep 15, 2009·International Journal of Food Microbiology·Marcella CammarotaMariateresa Giuliano
Nov 6, 2007·Clinics in Liver Disease·John M Vierling
Jul 11, 2007·Experimental Dermatology·Filippina MacalusoSabine Hoffjan
Mar 16, 2007·Clinical and Experimental Immunology·M R MilwardP R Cooper
Feb 6, 2009·Biotechnology Progress·Kim S Jones
Mar 3, 2012·Medicinal Research Reviews·Mona HedayatNima Rezaei
Oct 23, 2012·International Reviews of Immunology·Arash EsmaeiliNima Rezaei
Oct 23, 2012·International Reviews of Immunology·Faezeh Moghimpour BijaniNima Rezaei
Mar 17, 2011·Expert Opinion on Therapeutic Patents·Shaherin BasithSangdun Choi
Apr 23, 2013·International Immunopharmacology·Shirin Moossavi, Nima Rezaei
Oct 14, 2014·Frontiers in Immunology·Alison Mary RichGregory J Seymour
Jul 1, 2016·Expert Review of Clinical Immunology·Farzaneh Rahmani, Nima Rezaei
Mar 11, 2017·Expert Opinion on Therapeutic Targets·Amene Saghazadeh, Nima Rezaei
Mar 18, 2017·Immunotherapy·Shokrollah FarrokhiNima Rezaei
May 5, 2007·Nature Medicine·Roberto BaccalaArgyrios N Theofilopoulos
May 9, 2014·Reviews in the Neurosciences·Kaveh FadakarNima Rezaei
Jun 11, 2014·Reviews in the Neurosciences·Maziar GoosheNima Rezaei
Aug 28, 2014·Expert Review of Clinical Immunology·Maziar GoosheNima Rezaei
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amarendra PeguTodd A Reinhart
Jun 27, 2009·Immunopharmacology and Immunotoxicology·Amani Makkouk, Alexander M Abdelnoor
Apr 22, 2015·Expert Review of Clinical Immunology·Dalia S Ashour

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