Therapeutic Targeting of Repurposed Anticancer Drugs in Alzheimer's Disease: Using the Multiomics Approach.

ACS Omega
Dia Advani, Pravir Kumar

Abstract

The complexity and heterogeneity of multiple pathological features make Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an inexpensive and reliable approach to redirect the existing drugs for new indications. The current study aims to study the possibility of repurposing approved anticancer drugs for AD treatment. We proposed an in silico pipeline based on "omics" data mining that combines genomics, transcriptomics, and metabolomics studies. We aimed to validate the neuroprotective properties of repurposed drugs and to identify the possible mechanism of action of the proposed drugs in AD. We generated a list of AD-related genes and then searched DrugBank database and Therapeutic Target Database to find anticancer drugs related to potential AD targets. Specifically, we researched the available approved anticancer drugs and excluded the information of investigational and experimental drugs. We developed a computational pipeline to prioritize the anticancer drugs having a close association with AD targets. From data mining, we generated a list of 2914 AD-related genes and obtained 49 potential druggable targets by functional enrichment analysis. The protein-protein interaction (PPI) studies for these...Continue Reading

References

Feb 5, 2003·Neuro-Signals·Xiongwei ZhuMark A Smith
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Feb 1, 2005·Journal of Neuroscience Research·Irina J Fox, Harley I Kornblum
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Akihiko Takashima
Jan 12, 2007·Biochimica Et Biophysica Acta·John CaltagaroneRobert Bowser
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·M Paul Murphy, Harry LeVine
Jan 19, 2010·Biochimica Et Biophysica Acta·Eun Kyung Kim, Eui-Ju Choi
May 18, 2011·Nucleic Acids Research·Tyler W H BackmanThomas Girke
Jan 31, 2012·Chemistry & Biology·Markus SchirleBernhard Kuster
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Gary J PattiGary Siuzdak
Sep 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lei WangYi Zhong
Nov 30, 2012·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Oct 25, 2013·Journal of Medicinal Chemistry·Gerald MaggioraJürgen Bajorath
Jun 7, 2014·Frontiers in Molecular Neuroscience·María Llorens-MartínJesús Avila
Nov 22, 2015·Nucleic Acids Research·Damian SzklarczykMichael Kuhn
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Lisbell D EstradaAlejandra R Alvarez
Nov 12, 2016·Journal of Alzheimer's Disease : JAD·Fiammetta MonacelliAlessio Nencioni
Jan 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·William J NetzerVictor Bustos
Apr 1, 2017·Nature Reviews. Neuroscience·Ulrike C MüllerMartin Korte
Sep 5, 2017·Journal of Alzheimer's Disease : JAD·Monica JavidniaCharbel E-H Moussa
Sep 30, 2017·Nature Reviews. Neurology·Jun WangYan-Jiang Wang
Nov 11, 2017·Nucleic Acids Research·David S WishartMichael Wilson
Nov 15, 2017·Nucleic Acids Research·Denise N SlenterEgon L Willighagen
Nov 16, 2017·Nucleic Acids Research·David S WishartAugustin Scalbert
Dec 12, 2017·Journal of Alzheimer's Disease : JAD·Rachel HarrisSeth Love
Dec 23, 2017·Frontiers in Pharmacology·Jayne-Louise E PritchardDylan M Glubb
Jan 5, 2018·Genes·Yuanliang YanZhicheng Gong
Feb 24, 2018·Frontiers in Aging Neuroscience·Soghra BagheriAli A Saboury
May 13, 2018·Pharmaceuticals·Fernando DurãesEmília Sousa

❮ Previous
Next ❯

Software Mentioned

CoDReS
DAVID functional annotation set to diseases ( GS2D )
SwissADME
Bioplanet
GEO2R
CentiScaPe app
WikiPathways
Molecular Interaction Search Tool ( MIST )
DAVID
ChemMine

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.