Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation?

Antioxidants & Redox Signaling
Jeannette N Stankowski, Rishi Gupta

Abstract

The development of a suitable neuroprotective agent to treat ischemic stroke has failed when transitioned to the clinical setting. An understanding of the molecular mechanisms involved in neuronal injury during ischemic stroke is important, but must be placed in the clinical context. Current therapeutic targets have focused on the preservation of the ischemic penumbra in the hope of improving clinical outcomes. Unfortunately, most patients in the ultra-early time windows harbor penumbra but have tremendous variability in the size of the core infarct, the ultimate predictor of prognosis. Understanding this variability may allow for proper patient selection that may better correlate to bench models. Reperfusion therapies are rapidly evolving and have been shown to improve clinical outcomes. The use of neuroprotective agents to prolong time windows prior to reperfusion or to prevent reperfusion injury may present future therapeutic targets for the treatment of ischemic stroke. We review the molecular pathways and the clinical context from which future targets may be identified.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroW A Pulsinelli
Oct 1, 1991·Journal of Applied Physiology·R J TraystmanR C Koehler
Jan 1, 1995·Stroke; a Journal of Cerebral Circulation·S E Smith, B S Meldrum
May 1, 1994·Progress in Neurobiology·M Erecińska, I A Silver
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q ChenH Chen
Jun 17, 1996·Neuroreport·S A LoddickN J Rothwell
Nov 22, 1997·Stroke; a Journal of Cerebral Circulation·R C CrumrineB R Cooper
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·P E ChabrierS Moncada
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Jan 9, 2001·Trends in Cell Biology·H M Beere, D R Green
Jan 12, 2001·Journal of Neurophysiology·I Joshi, R D Andrew
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V BrunoF Nicoletti
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·John N FinkGottfried Schlaug
May 31, 2002·Pharmacological Reviews·Yossi Gilgun-SherkiDaniel Offen
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Gabriel T LiberatoreRobert L Medcalf
Apr 2, 2003·Molecular Neurobiology·Brigitte OnténienteChristelle Guégan
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Aug 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kyung-Min NohMichael V L Bennett
Dec 21, 2005·Brain : a Journal of Neurology·Martin FabriciusMartin Lauritzen
May 19, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baosong LiuQi Wan
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seong-Woon YuValina L Dawson
Jan 16, 2007·Brain Research Reviews·Suresh L MehtaRam Raghubir
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Joung-Ho Rha, Jeffrey L Saver
Apr 11, 2007·Annals of Neurology·Sean I Savitz, Marc Fisher
Jun 15, 2007·Journal of the Peripheral Nervous System : JPNS·Haruyasu IidaPhillip A Low
Mar 1, 2008·Neuropharmacology·Kristian P DoyleMary P Stenzel-Poore
Mar 13, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jose P Lopez-AtalayaDenis Vivien
Apr 9, 2008·Free Radical Biology & Medicine·Steven R Danielson, Julie K Andersen
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Aneesh B Singhal

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Citations

Mar 8, 2013·Journal of Neurointerventional Surgery·Christopher M HornRishi Gupta
May 13, 2014·BioMed Research International·Junying CaiYanhui Hu
Jul 22, 2011·Stem Cells International·Serpen DurnaogluKursad Genc
Dec 2, 2011·Journal of Aging Research·Mario Di Napoli, Imtiaz M Shah
Jan 18, 2013·Stroke Research and Treatment·Michael P Kahle, Gregory J Bix
Sep 28, 2012·Cellular and Molecular Life Sciences : CMLS·Xiaozhou HeYing Xia
Sep 26, 2013·The International Journal of Neuroscience·Huaxing MengJin Zhang
Dec 30, 2014·Annals of Clinical and Translational Neurology·Jong Youl KimWenhan Chang
Mar 1, 2014·ISRN Neurology·Arshad Majid
Apr 11, 2017·Expert Opinion on Pharmacotherapy·Brandon R ChristopheE Sander Connolly
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ana I CasasHarald H H W Schmidt
Oct 12, 2018·Cellular and Molecular Neurobiology·Rachida GuennounMichael Schumacher
Sep 21, 2013·The Journal of Pharmacology and Experimental Therapeutics·Cornelius LehaneMatjaz Humar
Jan 17, 2020·The European Journal of Neuroscience·Kathleen E Fifield, Jacqueline L Vanderluit
Apr 13, 2017·Journal of Nanobiotechnology·Andrés Da Silva-CandalJosé Castillo
May 29, 2018·Clinical Science·Douglas M BennionColin Sumners
Mar 19, 2019·The Journal of Clinical Investigation·Ana I CasasHarald Hhw Schmidt
Mar 19, 2019·Frontiers in Physiology·Marie StricklandAnis Larbi
Nov 24, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Terrie M Williams, Randall W Davis
Mar 14, 2021·Cellular and Molecular Neurobiology·Chang-Xiong GongQing-Wu Yang
Jul 23, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoyan ZhuRachida Guennoun
Jun 24, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Giorgio Fm CattaneoStephan Meckel

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