PMID: 11921424Mar 29, 2002Paper

Therapeutic targets in the management of Type 1 diabetes

Diabetes/metabolism Research and Reviews
P D Home

Abstract

For historical reasons, diabetes has long been linked with blood and urine glucose control, partly because these were clearly linked to acute symptoms, and partly because glucose became measurable around 200 years ago. Today it is recognized that there is far more to diabetes than simply monitoring symptoms and blood glucose. Intensive management has an impact on the quality of life. Late complications have their own risk factors and markers. Monitoring and early detection of these risk factors and markers can lead to changes in treatment before tissue damage is too severe. Accordingly, professionals now find themselves monitoring a range of adverse outcomes, markers for adverse outcomes, risk factors and risk markers for microvascular and arterial disease, acute complications of therapy, and the care structures needed to deliver this. Adverse outcomes lend themselves to targets for complication control in populations, and markers of adverse outcomes (such as retinopathy and raised albumin excretion rate) in treatment cohorts. Surveillance systems will have targets for yearly recall and review of early complications. Metabolic (surrogate) outcomes can be monitored in individual patients, but monitoring is only of value in so fa...Continue Reading

References

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Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Apr 22, 2006·Arquivos brasileiros de endocrinologia e metabologia·Domingos MalerbiSergio Atala Dib

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