Therapeutic Use of Antibiotic-loaded Bone Cement in the Treatment of Hip and Knee Joint Infections

Journal of Bone and Joint Infection
Konstantinos Anagnostakos

Abstract

The use of antibiotic-loaded cement spacers is an established method in the management of periprosthetic hip and knee joint infections. Despite inconsistencies among published studies, data shows that infection control rates exceed 90% with two-stage exchange arthroplasty. The present work reviews the current literature about antibiotic-loaded cement spacers and concentrates on the indications for spacer implantation, spacer production details, antibiotic impregnation, pharmacokinetic properties, clinical success, mechanical complications, and systemic safety.

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Citations

Mar 5, 2019·Advanced Healthcare Materials·Daniel CohnRaju Ramanujan
Feb 1, 2018·Expert Review of Medical Devices·Konstantinos Anagnostakos, Bernd Fink
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Satoru EgawaShinichi Sotome
Apr 21, 2020·Veterinary Surgery : VS·Chris R M HagenThomas W G Gibson
May 23, 2017·Journal of Bone and Joint Infection·Antonia F Chen, Heinz Winkler
Aug 22, 2020·Biomaterials Science·Thomas J HallSophie C Cox
Mar 28, 2019·Bone & Joint Research·M StravinskasL Lidgren
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Jun 10, 2020·International Journal of Molecular Sciences·Kosuke HamajimaTakahiro Ogawa
Oct 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Valerie ChiangPhilip H Li
Dec 29, 2020·World Journal of Orthopedics·Zachary C LumJohn P Meehan
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Lydia M Mensah, Brian J Love
Apr 8, 2021·ACS Biomaterials Science & Engineering·Deepa GargAbhay Sachdev
Oct 5, 2021·Orthopaedic Surgery·Hetzmannseder SophieKühn Klaus-Dieter
Oct 8, 2021·Orthopedics·Alexus M CooperJavad Parvizi

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Methods Mentioned

BETA
total hip arthroplasty

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