May 11, 2020

Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review

Travel Medicine and Infectious Disease
Anwar M HashemZiad A Memish

Abstract

The rapidly spreading Coronavirus Disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), represents an unprecedented serious challenge to the global public health community. The extremely rapid international spread of the disease with significant morbidity and mortality made finding possible therapeutic interventions a global priority. While approved specific antiviral drugs against SARS-CoV-2 are still lacking, a large number of existing drugs are being explored as a possible treatment for COVID-19 infected patients. Recent publications have re-examined the use of Chloroquine (CQ) and/or Hydroxychloroquine (HCQ) as a potential therapeutic option for these patients. In an attempt to explore the evidence that supports their use in COVID-19 patients, we comprehensively reviewed the previous studies which used CQ or HCQ as an antiviral treatment. Both CQ and HCQ demonstrated promising in vitro results, however, such data have not yet been translated into meaningful in vivo studies. While few clinical trials have suggested some beneficial effects of CQ and HCQ in COVID-19 patients, most of the reported data are still preliminary. Given the current uncertainty, it is worth being mindfu...Continue Reading

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Mentioned in this Paper

Pharmacologic Substance
In Vivo
Chloroquine
N protein, Severe acute respiratory syndrome virus
Study
Hydroxychloroquine
Virus Diseases
Public Health Service
Clinical Trials
Acute Respiratory Disease

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