Therapeutic vaccines against human papillomavirus and cervical cancer.

The Open Virology Journal
Angel Cid-Arregui

Abstract

Cervical cancer and its precursor intra-epithelial lesions are linked to infection by a subset of so-called "highrisk" human papillomavirus types, which are estimated to infect nearly four hundred million women worldwide. Two prophylactic vaccines have been commercialized recently targeting HPV16 and 18, the most prevalent viral types found in cervical cancer, which operate through induction of capsid-specific neutralizing antibodies. However, in patients with persistent infection these vaccines have not been found to protect against progression to neoplasia. Attempts are being made to develop therapeutic vaccines targeting nonstructural early viral proteins. Among these, E6 and E7 are the preferred targets, since they are essential for induction and maintenance of the malignant phenotype and are constitutively expressed by the transformed epithelial cells. Here are reviewed the most relevant potential vaccines based on HPV early antigens that have shown efficacy in preclinical models and that are being tested in clinical studies, which should determine their therapeutic capacity for eradicating HPV-induced premalignant and malignant lesions and cure cervical cancer.

Citations

Jul 23, 2011·International Journal of Cancer. Journal International Du Cancer·María L CeruttiGonzalo de Prat-Gay
Mar 9, 2011·International Journal of Cancer. Journal International Du Cancer·Loane DecrausazDenise Nardelli-Haefliger
May 2, 2015·Immunologic Research·Mohammed WahiduzzamanNeeta Singh
Aug 17, 2012·Human Vaccines & Immunotherapeutics·Houda BoukhebzaGeneviève Inchauspé
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karin Hellner, Karl Münger
Dec 7, 2013·Clinical and Vaccine Immunology : CVI·Christelle Remy-ZillerXavier Préville
Mar 18, 2019·Archives of Pharmacal Research·Joohee JungEun Kyung Choi
Feb 12, 2015·American Journal of Lifestyle Medicine·Rafael MañonJennifer Tseng
Sep 23, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Changxing LiuNiels C Kokot

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Methods Mentioned

BETA
transfection
biopsy
biopsies
ELISA
hysterectomy

Clinical Trials Mentioned

NCT00264732

Software Mentioned

Xenova

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