Therapeutic vaccines for chronic infections

Science
Brigitte AutranPatrice Debre

Abstract

Therapeutic vaccines aim to prevent severe complications of a chronic infection by reinforcing host defenses when some immune control, albeit insufficient, can already be demonstrated and when a conventional antimicrobial therapy either is not available or has limited efficacy. We focus on the rationale and challenges behind this still controversial strategy and provide examples from three major chronic infectious diseases- human immunodeficiency virus, hepatitis B virus, and human papillomavirus-for which the efficacy of therapeutic vaccines is currently being evaluated.

References

Mar 1, 1994·CA: a Cancer Journal for Clinicians·P Boffetta, D M Parkin
Aug 1, 1996·Current Opinion in Immunology·B AutranG Haas
Feb 10, 1999·The Journal of Infectious Diseases·C J LaceyJ S Roberts
Oct 12, 2000·Nature·E S RosenbergB D Walker
Jan 13, 2001·Current Opinion in Immunology·S Gallucci, P Matzinger
Feb 24, 2001·Science·B Autran, G Carcelain
Jul 14, 2001·Journal of Hepatology·S PolUNKNOWN Multicenter study group
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
Aug 3, 2002·Nature Reviews. Immunology·Stephen C Jameson
Nov 22, 2002·The New England Journal of Medicine·Laura A KoutskyUNKNOWN Proof of Principle Study Investigators
Jan 15, 2003·Clinical Microbiology Reviews·Eileen M Burd
Mar 3, 2004·Nature Medicine·Ronald C Desrosiers
Mar 23, 2004·Current Drug Targets. Inflammation and Allergy·Kazuhiro Hanazaki
May 12, 2004·Current Opinion in Immunology·Benedita Rocha, Corinne Tanchot

❮ Previous
Next ❯

Citations

Mar 3, 2007·Digestive Diseases and Sciences·Gary L DavisGyongyi Szabo
Aug 11, 2005·Current HIV/AIDS Reports·Yves Lévy
Apr 2, 2013·Lancet·Christine KatlamaRafick P Sekaly
Apr 22, 2009·Immunology and Cell Biology·Eugene MaraskovskyDebbie Drane
Aug 12, 2009·Immunology and Cell Biology·Núria ClimentRafael Franco
Sep 21, 2011·Immunology and Cell Biology·Jose M Martinez-NavioRafael Franco
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria Candela IglesiasPierre Charneau
Mar 12, 2008·The Journal of Experimental Medicine·David G BrooksMichael B A Oldstone
Mar 14, 2013·The Journal of Infectious Diseases·Joseph P CasazzaUNKNOWN VRC 101 Study Team
Mar 23, 2006·Annual Review of Immunology·Andrew J McMichael
Jun 4, 2010·Drugs·Sarah L PettSean Emery
Mar 10, 2012·Immunotherapy·Felipe García
Jul 20, 2010·Immunotherapy·Jean-Pierre Routy, Charles Nicolette
Aug 22, 2007·Journal of Biomedicine & Biotechnology·Eric Dumonteil
Jul 1, 2006·Current Opinion in HIV and AIDS·Brigitte AutranChristine Katlama
Mar 16, 2013·Current Opinion in HIV and AIDS·Brigitte AutranCharline Bacchus
Aug 25, 2005·Expert Review of Vaccines·Lucy Dorrell
Apr 2, 2008·Expert Review of Vaccines·Yukai HeLouis D Falo
Oct 13, 2007·Expert Review of Vaccines·Debbie DraneEugene Maraskovsky
Feb 19, 2016·Human Vaccines & Immunotherapeutics·Meagan A BarryPeter J Hotez
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aleksandar F Radovic-MorenoSergei M Gryaznov
Jan 15, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ingrid KarlssonAnders Fomsgaard
Nov 7, 2015·European Journal of Immunology·Brigitte Autran
Aug 30, 2012·European Journal of Immunology·Alexandre HarariPierre-Alexandre Bart
Jan 6, 2009·Annals of the New York Academy of Sciences·Israel Alejandro Quijano-HernandezEric Dumonteil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.