Therapeutic value of neoadjuvant intra-arterial chemotherapy (cisplatin) and irradiation for locally advanced uterine cervical cancer

Gynecologic Oncology
T ToitaS Sawada

Abstract

We analyzed long-term treatment results in 51 patients with locally advanced uterine cervical carcinoma (IIB, 4; IIIB, 43; IVA, 4) treated with neoadjuvant intra-arterial (I-A) chemotherapy (cisplatin) via the uterine artery and irradiation. Thirty patients (58.8%) developed recurrence. Twelve had pelvic recurrence alone, 8 had distant metastases alone, and 10 had both pelvic and distant failure. The 5-year cumulative pelvic control rate, absolute survival rate, and disease-free survival rate were 55.3, 47.1, and 39.4%, respectively. Eight of 51 patients (15.7%) suffered late complications. These results suggest that our neoadjuvant I-A chemotherapy prior to irradiation has limited additional value for long-term prognosis in patients with locally advanced uterine cervical carcinoma.

References

Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·L SouhamiC R Freeman
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·R A Potish, L B Twiggs
Sep 1, 1992·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M.H.N. TattersallM. Coppleson

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Citations

Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Yuko KaneyasuKatsuhide Ito
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hao WenShumo Cai
Aug 15, 2014·Texas Heart Institute Journal·Alicia MecklaiMuhamed Saric
Jan 17, 2014·Journal of Obstetrics and Gynaecology of India·Uma SinghSabuhi Qureshi
Sep 2, 2020·The Journal of International Medical Research·Shu-Li YangYu-Mei Wu

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