Therapeutic value of spinal cord stimulation in irritable bowel syndrome: a randomized crossover pilot study

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Göran LindPer M Hellström

Abstract

Irritable bowel syndrome (IBS) is characterized by abdominal pain and changed bowel habits. Spinal cord stimulation (SCS) has been used for treatment of chronic pain syndromes. Animal studies have shown SCS to reduce the reaction to colonic balloon distension, known to be increased in IBS patients. To elucidate the potential for SCS as treatment for IBS, a pilot study was performed. Ten IBS patients (age 26-56 yr) were recruited. A SCS system with a four-polar electrode was implanted at the T5-T8 level. After a 2-wk run-in, a randomized, crossover design SCS during 6 wk was compared with no stimulation, with an ensuing stimulation period for 12 wk; total study period 28 wk. Patients recorded pain level, pain attacks, diarrheas, and global quality of life in a diary. At end of the study patients could choose to retain their SCS system or have it removed. Nine patients completed the whole trial. During stimulation periods the median pain scores were significantly reduced from visual analogue scale (VAS) 7 (4-8) to 3 (2.5-7) and to 4 (2-6) during early and late stimulation periods, respectively (P < 0.03-0.04). Pain attacks were numerically reduced. A few patients reported reduced number of diarrheas. After study termination, six ...Continue Reading

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Citations

Jul 16, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Rui V DuarteSam Eldabe
Nov 30, 2019·Inflammatory Bowel Diseases·Jiafei ChengJiande D Z Chen
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Jun 24, 2020·The Journal of Pain : Official Journal of the American Pain Society·Ewan McNicolSimon Thomson

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