Therapeutics for neonatal brain injury

Pharmacology & Therapeutics
Fernando F Gonzalez, Donna M Ferriero

Abstract

Neonatal brain injury is an important cause of death and neurodevelopmental delay. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to both early and late phases of cell damage and death. Therapies targeting these different pathways have shown potential in protecting the brain from ongoing injury. More recent therapies, such as growth factors, have demonstrated an ability to increase cell proliferation and repair over longer periods of time. Even though hypothermia, which decreases cerebral metabolism and possibly affects other mechanisms, may show some benefit in particular cases, no widely effective therapeutic interventions for human neonates exist. In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair.

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·A AhonenE Klinge
Sep 25, 1992·Biochemical Pharmacology·W PruzanskiP Vadas
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Jan 1, 1994·Acta Neuropathologica·J TowfighiJ Y Yager
May 1, 1994·Stroke; a Journal of Cerebral Circulation·C PalmerC Bero
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichM D Ginsberg
Nov 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·M LeveneR Hartley
Jan 15, 1996·The Journal of Clinical Investigation·B M JohnstonP D Gluckman
Jan 1, 1996·Annals of Neurology·D M HoltzmanD M Ferriero
Jan 15, 1997·The Journal of Clinical Investigation·A J GunnP D Gluckman
Jul 25, 1997·The Journal of Biological Chemistry·I Fridovich
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SakanakaR Sasaki
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HayashiY Itoyama
Oct 20, 1998·Seminars in Pediatric Neurology·H C Kinney, S A Back
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BernaudinE Petit
Sep 4, 1999·Biology of the Neonate·E ErgenekonY Atalay
Sep 15, 1999·Cellular and Molecular Life Sciences : CMLS·J L BoucherJ P Tenu
Oct 28, 1999·Clinical Neurology and Neurosurgery·K GücüyenerG Biberoglu
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Aug 29, 2000·Pediatric Research·G M Van LeeuwenA D Edwards
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L BrinesA Cerami
Sep 16, 2000·JAMA : the Journal of the American Medical Association·Y W Wu, J M Colford
Sep 20, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B R HuB K Siesjö
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Mar 29, 2001·Biology of the Neonate·G BuonocoreR Bracci
Oct 13, 2001·Developmental Neuroscience·R GeddesS J Vannucci
Oct 13, 2001·Developmental Neuroscience·D M Ferriero
Dec 6, 2001·Journal of Child Neurology·M E DilengeM I Shevell

❮ Previous
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Citations

Jul 27, 2011·Neuroscience Bulletin·Daniel Alonso-AlconadaEnrique Hilario
Jan 29, 2011·Stroke; a Journal of Cerebral Circulation·Wanqiu ChenJohn H Zhang
Jan 28, 2014·European Journal of Pharmacology·Huizhen ZhangWeidong Zhang
Jun 23, 2011·European Journal of Pharmacology·Xiangmin ZhangZhan Zhang
Feb 11, 2012·Zhonghua er ke za zhi. Chinese journal of pediatrics·Tao XiongDe-zhi Mu
Feb 17, 2009·Pediatric Neurology·Jerome Y YagerAmy M Black
Sep 17, 2015·Experimental Neurology·Jaylyn WaddellMargaret M McCarthy
Feb 2, 2010·Neurobiology of Disease·Damjan OsredkarDonna M Ferriero
Mar 22, 2014·Biochemical Society Transactions·Shyama D PatelSusan J Vannucci
Mar 27, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Slobodan D SpasojevicSinisa M Babovic
Oct 31, 2013·Seminars in Ophthalmology·Ian R Gorovoy, Jordan C Vaccari
Jun 29, 2015·Brain Research Bulletin·Verónica CampanilleRocío Castilla
Sep 1, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dan LiYongsheng Jiang
Nov 11, 2016·Expert Review of Neurotherapeutics·Edibe Pembegül YıldızBurak Tatlı
May 3, 2011·Journal of Child Neurology·Joelle Nsimire Chabwine, Serge Vanden Eijnden
Dec 4, 2009·Anesthesia and Analgesia·Catherine E Creeley, John W Olney
Apr 14, 2010·Clinical Pharmacokinetics·Marcel P H van den BroekCarin M A Rademaker
Jan 1, 2013·Brain Sciences·Felipe Goñi de CerioEnrique Hilario
Feb 1, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tao XiongDonna Ferriero
Jun 22, 2018·Neural Regeneration Research·Shenandoah RobinsonLauren L Jantzie
Feb 16, 2020·Journal of Neuroscience Research·Clémence Disdier, Barbara S Stonestreet
Oct 12, 2017·Frontiers in Cellular Neuroscience·Yonggang LuanYubin Dong

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