Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

International Journal of Molecular Sciences
Ju-Ryoung KimHyun Ah Kim

Abstract

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.

References

Apr 15, 1994·Biochemical and Biophysical Research Communications·D TaskiranC Evans
Feb 14, 1998·Annals of the Rheumatic Diseases·M V HurleyD J Newham
Oct 3, 2000·Arthritis and Rheumatism·M B Goldring
Oct 14, 2000·Archives of Biochemistry and Biophysics·A M LoeningM W Lark
Nov 23, 2000·Annals of the Rheumatic Diseases·F HéraudM F Harmand
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J S DayH Weinans
Jan 29, 2002·Current Pharmaceutical Design·L SalernoM A Siracusa
Apr 13, 2002·Osteoarthritis and Cartilage·K VuolteenahoE Moilanen
Aug 9, 2003·Arthritis and Rheumatism·L HaywoodD A Walsh
Oct 11, 2003·Veterinary Research Communications·C M Mortellaro
Jan 2, 2004·Aging Clinical and Experimental Research·Florenzo Iannone, Giovanni Lapadula
Jan 30, 2004·The New England Journal of Medicine·Pierre J MeunierJean-Yves Reginster
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Jean-Michel Dayer
Sep 24, 2004·Rheumatology·D T FelsonM P Lavalley
Dec 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Pierre D Delmas
Apr 1, 2005·Nature·Heather StantonAmanda J Fosang
Jun 28, 2005·Cancer Letters·Devanand Sarkar, Paul B Fisher
Sep 27, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christopher B ForsythRichard F Loeser
Jan 6, 2006·Scandinavian Journal of Rheumatology·C E VergunstP P Tak
Feb 24, 2006·The New England Journal of Medicine·David T Felson
Jun 1, 2006·Arthritis and Rheumatism·Darryl D'LimaMartin Lotz
Jan 6, 2007·Osteoarthritis and Cartilage·Peter M van der Kraan, Wim B van den Berg
Mar 1, 2007·Arthritis and Rheumatism·Solmaz SahebjamJohn S Mort
Dec 1, 2007·Arthritis and Rheumatism·Rik J U LoriesFrank P Luyten
Aug 9, 2008·Rheumatic Diseases Clinics of North America·Kim L BennellRana S Hinman
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mei ZhuDi Chen
Nov 11, 2008·Archives of Physical Medicine and Rehabilitation·Tuomas LiikavainioJari P Arokoski
Dec 9, 2008·The Medical Clinics of North America·Steven R Goldring
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rasheed AhmadMuhammad Zafarullah
May 12, 2009·Osteoarthritis and Cartilage·A Rehan YoussefW Herzog
May 14, 2009·Annals of the Rheumatic Diseases·L BacconnierS Fabre

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Citations

Apr 17, 2019·International Journal of Molecular Sciences·Chih-Hsin Tang
Jul 20, 2019·Cells·Moon-Chang ChoiYoonkyung Park
Dec 15, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Junaidi KhotibChrismawan Ardianto
Mar 9, 2020·Journal of Bone and Mineral Metabolism·Lian WangTao Li
Dec 14, 2019·Cell Biochemistry and Function·Wen-Feng XiaoMiao He
Jun 13, 2020·Journal of Cellular and Molecular Medicine·Hyemi LeeLi-Jung Kang
Jul 2, 2020·Journal of Pain Research·Mina WangBin Li
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Driss EhirchiouSonia Nasi
Jan 7, 2021·Tissue Engineering. Part C, Methods·Meagan J MakarczykHang Lin
Nov 22, 2020·International Journal of Molecular Sciences·Hitoshi TonomuraKenji Takahashi
Apr 4, 2021·International Journal of Molecular Sciences·Elena RezuşCiprian Rezuş

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT02471118
NCT03161093
NCT02683239
NCT03304379

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