Therapeutics targeting the fibrinolytic system.

Experimental & Molecular Medicine
Haili LinPeng Xu

Abstract

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.

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Sep 2, 2020·Cancer Metastasis Reviews·Alessandra V S FariaGwenny M Fuhler
Aug 28, 2020·Anais Da Academia Brasileira De Ciências·PlÍnio C Sathler
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Methods Mentioned

BETA
phage-display
ELISA
phage display
PAItrap

Software Mentioned

PAItrap

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