Therapies based on targeting Epstein-Barr virus lytic replication for EBV-associated malignancies

Cancer Science
Hongde LiYa Cao

Abstract

In recent years, Epstein-Barr virus (EBV) lytic infection has been shown to significantly contribute to carcinogenesis. Thus, therapies aimed at targeting the EBV lytic cycle have been developed as novel strategies for treatment of EBV-associated malignancies. In this review, focusing on the viral lytic proteins, we describe recent advances regarding the involvement of the EBV lytic cycle in carcinogenesis. Moreover, we further discuss 2 distinct EBV lytic cycle-targeted therapeutic strategies against EBV-induced malignancies. One of the strategies involves inhibition of the EBV lytic cycle by natural compounds known to have anti-EBV properties; another is to intentionally induce EBV lytic replication in combination with nucleotide analogues. Recent advances in EBV lytic-based strategies are beginning to show promise in the treatment and/or prevention of EBV-related tumors.

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Citations

Apr 2, 2020·Seminars in Immunopathology·Alexander Buschle, Wolfgang Hammerschmidt
Nov 17, 2019·Cancers·Chung-Chun WuJen-Yang Chen
Aug 11, 2019·Molecular Therapy. Nucleic Acids·Man WangKun Wang
Dec 22, 2021·Head & Neck·Wanpeng LiDehui Wang

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