Therapies to limit infarct size. Timing, dosage, and effectiveness

Postgraduate Medicine
J E Peterson, W W Emmot

Abstract

Rapid diagnosis of an evolving acute myocardial infarction and institution of thrombolytic therapy in appropriate patients can markedly decrease infarct size and thus reduce cardiovascular morbidity and mortality. Streptokinase (Kabikinase, Streptase) and recombinant tissue plasminogen activator (Activase) are both widely used, effective clot-dissolving agents. Patients who are not candidates for thrombolytic therapy can be treated with other methods, such as anticoagulant therapy, which can greatly reduce infarct size. Intravenous heparin, beta blockers, nitroglycerin, and aspirin have all been shown to limit infarct size, decrease mortality, or do both in patients with acute myocardial infarction.

References

Feb 1, 1989·Chest·J A CairnsE R Passamani
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Aug 18, 1988·The New England Journal of Medicine·UNKNOWN Multicenter Diltiazem Postinfarction Trial Research Group
Nov 1, 1987·Journal of the American College of Cardiology·E J TopolB S George
Jan 1, 1988·Progress in Cardiovascular Diseases·W W O'NeillB Pitt

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