Therapies to modulate gut microbiota: Past, present and future

World Journal of Gastroenterology : WJG
Akshita GuptaSahil Khanna

Abstract

The human gut microbiota comprises of a complex and diverse array of microorganisms, and over the years the interaction between human diseases and the gut microbiota has become a subject of growing interest. Disturbed microbial milieu in the gastrointestinal tract is central to the pathogenesis of several diseases including antibiotic-associated diarrhea and Clostridioides difficile infection (CDI). Manipulation of this microbial milieu to restore balance by microbial replacement therapies has proven to be a safe and effective treatment for recurrent CDI. There is considerable heterogeneity in various aspects of stool processing and administration for fecal microbiota transplantation (FMT) across different centers globally, and standardized microbioal replacement therapies offer an attractive alternative. The adverse effects associated with FMT are usually mild. However, there is paucity of data on long term safety of FMT and there is a need for further studies in this regard. With our increasing understanding of the host-microbiome interaction, there is immense potential for microbial replacement therapies to emerge as a treatment option for several diseases. The role of microbioal replacement therapies in diseases other than ...Continue Reading

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Apr 9, 2020·Expert Review of Anti-infective Therapy·Elida Voth, Sahil Khanna
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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT03183128
NCT02981316
NCT03110133

Software Mentioned

FMT

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