Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes

Frontiers in Immunology
Charles J KrogerRoland Tisch

Abstract

Type 1 diabetes (T1D) is an autoimmune disease that is generally considered to be T cell-driven. Accordingly, most strategies of immunotherapy for T1D prevention and treatment in the clinic have targeted the T cell compartment. To date, however, immunotherapy has had only limited clinical success. Although certain immunotherapies have promoted a protective effect, efficacy is often short-term and acquired immunity may be impacted. This has led to the consideration of combining different approaches with the goal of achieving a synergistic therapeutic response. In this review, we will discuss the status of various T1D therapeutic strategies tested in the clinic, as well as possible combinatorial approaches to restore β cell tolerance.

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Citations

Sep 3, 2020·Journal of Clinical Medicine·Przemysław BeikElżbieta Niechciał
Jan 16, 2019·F1000Research·Gisela M Vaitaitis, David H Wagner
Sep 11, 2020·Tissue Engineering. Part B, Reviews·Rachel E GurlinEsther Latres
Sep 29, 2020·Frontiers in Immunology·Wenjie Liang, Julien Diana
Feb 20, 2021·Frontiers in Immunology·Matthew ClarkRoland M Tisch
May 18, 2021·World Journal of Diabetes·William de Jesús Ríos-RíosHonorio Torres-Aguilar
Aug 11, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Inah CamayaSheila Donnelly
Aug 29, 2021·Pharmaceutics·Nolwenn TessierCatherine Martel

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Methods Mentioned

BETA
antisense oligodeoxynucleotides

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