Therapy control in oncology by circulating nucleosomes

Annals of the New York Academy of Sciences
S Holdenrieder, P Stieber

Abstract

The courses of circulating nucleosomes in the serum of patients with various solid tumors correlate with the clinical outcome after chemo- and radiotherapy. Already during the initial phase of treatment they showed considerable alterations consisting of a rapid increase followed by a decrease during the first therapeutic week. Among patients with advanced lung cancer undergoing chemotherapy, those patients who responded to therapy exhibited less pronounced increases and more complete decreases compared to those patients with insufficient response. In addition, response to therapy was correlated with stronger decreases of the precyclic baseline values from cycle 1 to 2 and from cycle 1 to 3. Thus, circulating nucleosomes are a valuable tool for the early prediction of therapeutic efficacy and can help to modulate therapy strategies early and on an individual basis.

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Citations

Sep 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oliver J StötzerStefan Holdenrieder
May 25, 2010·Nucleic Acids Research·Alain R ThierryFranck Molina
Jul 26, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andreas KremerDietrich Seidel
Jan 15, 2013·International Archives of Medicine·Ricardo MorenoFernando L Fonseca
Feb 1, 2009·Biomarkers in Medicine·Stig Linder, Ayodele Alaiya
Sep 26, 2013·International Journal of Molecular Sciences·Yahya I ElshimaliJaydutt V Vadgama
Jul 4, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Deepika ShuklaVivekanandhan Subbiah
Jun 24, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stefan HoldenriederPetra Stieber
Oct 8, 2008·Annals of the New York Academy of Sciences·Stefan HoldenriederPetra Stieber
Jun 5, 2013·International Journal of Cancer. Journal International Du Cancer·Christin WittwerStefan Holdenrieder
Dec 9, 2004·Biochimica Et Biophysica Acta·Jeff CummingsCaroline Dive
Sep 10, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O E Bryzgunova, P P Laktionov
Aug 7, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Julia LehnerStefan Holdenrieder
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Jernej PajekJana Lukac-Bajalo
Dec 25, 2008·Critical Reviews in Clinical Laboratory Sciences·Stefan Holdenrieder, Petra Stieber
Jul 26, 2005·Clinical Chemistry·Stefan HoldenriederY M Dennis Lo
May 26, 2005·Clinical Chemistry·Stefan HoldenriederPetra Stieber
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefan HoldenriederPetra Stieber
Jul 1, 2021·BMC Veterinary Research·Heather Wilson-RoblesMhammed Bougoussa

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