Therapy for acute pancreatitis with platelet-activating factor receptor antagonists.

World Journal of Gastroenterology : WJG
Chong ChenXiao-Hong Li

Abstract

Acute pancreatitis (AP) causes release of platelet-activating factor (PAF), which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF is a cell surface secretion of bioactive lipid, which could produce physiological and pathological effects by binding to its cell surface receptor called platelet-activating factor receptor (PAF-R). Studies showed that PAF participate in the occurrence and development of AP and administration of platelet-activating factor receptor antagonists (PAF-RAs) could significantly reduce local and systemic events after AP. PAF has also been implicated as a key mediator in the progression of severe AP, which can lead to complications and unacceptably high mortality rates. Several classes of compounds show significant PAF-RAs, and significant local and systemic effects on reducing inflammatory changes. As a preventive treatment, PAF-RA could block a series of PAF-mediated inflammatory injury and thus improve the prognosis of AP. This review introduces the important role of PAF-RA in the treatment of AP.

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Citations

Jul 2, 2010·World Journal of Gastroenterology : WJG·Vijith VijayanStephan Immenschuh
Jul 11, 2013·World Journal of Gastroenterology : WJG·Shi-Hai XiaWei Xu
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Eirini NitodaMichael Koutsilieris
Jul 6, 2010·Pharmacology & Therapeutics·José M López-NovoaFrancisco J López-Hernández
Jul 9, 2009·Journal of Zhejiang University. Science. B·Xi-Ping ZhangJie Zhang
Feb 18, 2017·International Journal of Molecular Sciences·Paulina DumnickaBeata Kuśnierz-Cabala
May 15, 2018·Nutrients·Alexandros TsouprasIoannis Zabetakis
Nov 16, 2013·Molecular and Cellular Biochemistry·Cristina CarrascoJosé A Pariente
Dec 11, 2014·World Journal of Gastroenterology : WJG·Swetha KambhampatiAida Habtezion
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Aug 24, 2019·Free Radical Biology & Medicine·Kandahalli Venkataranganayaka AbhilashaGopal Kedihithlu Marathe
Jul 11, 2021·Molecular Biology Reports·Martyna GachowskaJulita Kulbacka

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