[Therapy-induced effects in normal tissue].

Der Radiologe
G van Kaick, S Delorme

Abstract

More than 50% of cancer patients survive for more than 5 years, owing to modern and effective treatment. Therefore, long-term sequelae of treatment are more frequently seen than in the past. Such effects on normal tissue may both mimic and obscure tumor recurrences. Besides the direct consequences of surgery, tissue damage due to radiation or chemotherapy frequently cause problems in differential diagnosis. Among the numerous sequelae of radiotherapy, the most prominent are disturbance of the blood-brain barrier, radiation pneumonitis, osteodystrophy and osteoradionecrosis, fatty changes of bone marrow, or increased radiodensity of breast parenchyma. Chemotherapy may cause, e.g., diffuse abnormalities of white matter, pneumonitis and lung fibrosis, cardiomyopathy, or diffuse and patchy changes in bone marrow signals in MRI. The most devastating long-term complications are secondary cancers and leukemia induced by both radiotherapy and chemotherapy.

References

Sep 7, 1994·Journal of the National Cancer Institute·R E CurtisM J Schymura
Dec 1, 1993·Radiology·M Müller-SchimpfleG van Kaick
Jul 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·H U KauczorG van Kaick
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·J M MillsL J Solin
Jul 11, 2002·Radiation Research·Dale L PrestonJohn D Boice
May 7, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K K Herfarth, J Debus
Jul 27, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Anca-Ligia GrosuMichael Molls
Oct 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lois B Travis
Aug 29, 2007·Clinics in Liver Disease·Edmundo A Rodriguez-Frias, William M Lee

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