Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies

Frontiers in Oncology
Sergi BenaventeJuan Lorente

Abstract

Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. At the same time, the clinical successes achieved with minimally invasive and optically-guided surgery and image-guided and ablative radiation strategies have been successfully implemented in clinical care. More effective, localized and safer treatments have fueled strong research interest in radioimmunotherapy, which has shown the potential immunomodulatory effects of ionizing radiation. However, increasingly more observations suggest that immunosuppressive changes, metabolic remodeling, and angiogenic responses in the local tumor microenvironment play a central role in tumor recurrence. In this review, we address challenges to identify responders vs. non-responders to the immune checkpoint blockade, discuss recent developments in combinations of immunotherapy and radiotherapy for clinical evaluation, and consider the clinical impact of immunosuppressive changes in the tumor microenvironment in the context of surgery and radiation. Since the therapy-in...Continue Reading

References

Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Chien-Sheng TsaiJi-Hong Hong
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gerben J van der BijMarjolein van Egmond
Dec 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jarrod PredinaSunil Singhal
Feb 20, 2013·Journal of Cell Science·Frances R BalkwillThorsten Hagemann
Sep 4, 2013·The Journal of Clinical Investigation·Christopher T HensleyRalph J DeBerardinis
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Triantafyllos Stylianopoulos, Rakesh K Jain
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christine FeigDouglas T Fearon
Mar 17, 2015·Mutation Research·Ammar Al-MayahMunira Kadhim
Apr 4, 2015·Science·Johanna A Joyce, Douglas T Fearon
Apr 14, 2015·Seminars in Cancer Biology·Stephanie C CaseyDean W Felsher
Aug 28, 2015·American Journal of Physiology. Cell Physiology·Muhammad Zaeem NomanSalem Chouaib
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Jun 25, 2016·Nature Reviews. Cancer·Camilla EngblomMikael J Pittet
Aug 24, 2016·Nature Reviews. Cancer·Raghu Kalluri
Oct 9, 2016·The New England Journal of Medicine·Alexander M M EggermontAlessandro Testori
Nov 27, 2016·International Journal of Cancer. Journal International Du Cancer·Sofia AvnetNicola Baldini
Feb 12, 2017·Cell·Padmanee SharmaAntoni Ribas
Mar 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Carlos Carmona-FontaineJoao B Xavier
Mar 18, 2017·Nature Reviews. Cancer·Héctor PeinadoDavid Lyden
Apr 12, 2017·Cancer Immunology Research·Daniel Y WangElizabeth I Buchbinder
Jul 1, 2017·Journal of Cellular Physiology·Elham SafarzadehBehzad Baradaran
Oct 6, 2017·Science Translational Medicine·Matthias Pinter, Rakesh K Jain
Nov 25, 2017·Pigment Cell & Melanoma Research·Jenny H J LeeGeorgina V Long
Jan 10, 2018·Frontiers in Oncology·Tadanobu NagayaHisataka Kobayashi
Mar 7, 2018·Nature Reviews. Clinical Oncology·Dai FukumuraRakesh K Jain
Mar 13, 2018·Frontiers in Immunology·Soumaya KouidhiAmel Benammar Elgaaied
Apr 5, 2018·Frontiers in Oncology·Chitra Rajagopal, K B Harikumar
Apr 10, 2018·Immunity·Vésteinn ThorssonIlya Shmulevich
Apr 11, 2018·Scientific Reports·Ryan K OroscoQuyen T Nguyen

❮ Previous
Next ❯

Citations

May 1, 2021·Metabolites·Ezequiel MonferrerTomás Álvaro Naranjo
Jun 12, 2021·Frontiers in Oncology·Isaacson B AdelaniSolomon O Rotimi
Aug 13, 2021·Oxidative Medicine and Cellular Longevity·Salome Sadat SalehiManouchehr Nakhjavani

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence imaging
surgical resection
amino acid exchange

Clinical Trials Mentioned

NCT02417662
NCT03137771
NCT02364557
NCT03862911
NCT03721341
NCT03686215
NCT03563248

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.