Therapy-induced morphological changes in lung cancer

Der Pathologe
K Junker

Abstract

Especially patients with locally advanced non-small cell lung cancer, but also patients with small cell lung cancer without distant metastases are increasingly treated by means of neoadjuvant multimodality therapy. In corresponding resection specimens of primary tumours and lymph nodes, the extent of therapy-induced tumour regression represents an independent prognostic factor. After neoadjuvant therapy, different-sized target-like foci with central necrosis, adjoining narrow foam cell rim, peripheral vascular granulation tissue and transition into a marked scarry fibrosis can be established in the former tumour area. Morphological changes indicating therapy-induced tumour regression can be graded according to the "Bochum regression grading" system. Cytomorphological changes do not allow reliable conclusions to be drawn about the success of the applied neoadjuvant therapy. In resection specimens, they should not form the basis of a cytopathologic grading or lead to the diagnosis of "large cell anaplastic carcinoma".

References

Feb 1, 1993·British Journal of Cancer·A H Wyllie
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N C ChoiH Grillo
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·K JunkerK M Müller
Jun 29, 2001·Journal of Clinical Pathology·A R Gibbs, F B Thunnissen
Dec 18, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E Galligioni, A Ferro

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Citations

Jan 17, 2009·Der Pathologe·K Junker, I Petersen
Mar 23, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Hans Theodor EichRolf-Peter Müller
Aug 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Babett BartlingAndreas Simm
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin DongYuzhuo Wang

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