Therapy induced regressive changes of prostate cancer

Der Pathologe
B Helpap, J Köllermann

Abstract

Regressive changes following pretreatment of prostate cancer may represent a big challenge for the histopathologist not familiar with the assessment of pretreated specimens. Characteristic changes after antiandrogen therapy in non-malignant prostate tissue include glandular atrophy, basal cell prominence and/or basal cell hyperplasia as well as a hypercellular stroma. Morphologic changes in prostate cancer include cytoplasmic clearing and vacuolization, nuclear pyknosis and even complete cell destruction. On the glandular level, changes are characterized by various degrees of involutional changes, ranging from almost non-regressive tumor glands to complete glandular disruption with scattered isolated tumor cells dispersed in the stroma. Knowledge about these changes, the selective use of immunohistochemistry as well as a very thorough histological workup is essential for the correct assessment of these specimens.

References

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·B Helpap, V Koch
Sep 7, 2002·World Journal of Urology·Burkhard Helpap
Sep 17, 2002·Urology·Peter R CarrollUNKNOWN Second International Conference on Newer Approaches to Androgen Deprivation Therapy (ADT) in Prostate Cancer
Feb 27, 2003·The American Journal of Surgical Pathology·Ming ZhouMark A Rubin

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Citations

Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jens KöllermannKlaus Pantel

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