Mar 1, 1977

Therapy of advanced squamous carcinoma of the lung: cyclophosphamide vesus "COMB"

G P BodeyO S Selawry


The four-drug combination of cyclophosphamide, vincristine, methyl CCNU and bleomycin was compared to CTX alone in a prospective randomized trial. Only one of 20 patients treated with COMB and one of 27 patients treated with CTX achieved a partial response. CTX was associated with a significantly better survival than COMB among patients who were ambulatory at onset of therapy. Survival among non-ambulatory patients was similar with both regimens.

Mentioned in this Paper

Antineoplastic Agents
Squamous Cell Carcinoma
Carcinoma, Lewis Lung
Cyclophosphamide, (S)-Isomer
Malignant Neoplasm of Lung

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