PMID: 9448917Feb 4, 1998Paper

Therapy of Crohn's disease in childhood

Baillière's Clinical Gastroenterology
J A Walker-Smith

Abstract

The aim of therapy in Crohn's disease in childhood is to induce and to maintain a remission of disease activity so that normal growth and development of the child may occur. Enteral nutrition may now be recommended as the first-line treatment for most children with Crohn's disease. However, the evidence for remission is better for children with Crohn's disease of the small intestine rather than of the large intestine. There is evidence that amino acid feeds (elemental), whole protein (polymeric) and protein hydrolysate feeds (semi-elemental) may all be successful. Such a therapeutic approach can lead to healing of the mucosa and down-regulation of inflammation. However, in some cases surgery is required, particularly in children with growth failure and delayed puberty. Drug therapy also continues to have a role in therapy especially with severe colonic disease.

References

Jul 1, 1990·European Journal of Pediatrics·A B LipsonJ A Walker-Smith
Feb 1, 1973·The American Journal of Digestive Diseases·G L GiorginiW R Thayer
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·J NavarroC Polonovski
Sep 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·S K ChongL H Rees
May 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·C L MorinN Lapointe
Sep 1, 1994·Archives of Disease in Childhood·S NichollsJ A Walker-Smith
Jan 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·C P BraeggerT T MacDonald
May 1, 1994·Gut·C D GillenR N Allan
May 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·R M BeattieJ A Walker-Smith
May 1, 1997·Archives of Disease in Childhood·W HyerA McLean

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Citations

Sep 2, 1998·Transplantation Proceedings·P VajroF Migliaro
Jul 25, 2000·Postgraduate Medical Journal·J A Walker-Smith
Aug 11, 2000·Paediatric Drugs·R M Beattie
Jul 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·A M Griffiths
Jul 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·R B HeuschkelA E Baird

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