Therapy of dementia with antipsychotics and antidepressives

Der Nervenarzt
L Frölich, L Hausner

Abstract

In dementia depressive symptoms, anxiety, hallucinations and delusions often occur and are accompanied by unspecific behavioral changes. A targeted pharmacotherapy is complicated by the underlying cognitive impairment and physical comorbidities. The current review focusses on recent evidence on the use of antidepressives and antipsychotics for psychotic disturbances, agitation and depression in dementia and analyzes currently published randomized controlled clinical trials and meta-analyses. The evidence on the use of antipsychotics for different indications favors risperidone, with lower evidence levels for quetiapine and aripiprazole, whereas haloperidol should be avoided. Increased mortality and the risk of cerebrovascular events due to antipsychotics are of major concern. With respect to antidepressives, the benefit of antidepressive pharmacotherapy in dementia is critically discussed because of limited efficacy and increased side effects; however, selective serotonin reuptake inhibitors (SSRI), such as citalopram and sertraline have demonstrated efficacy on neuropsychiatric behavioral symptoms in general. These conclusions on the risk-benefit ratio of antidepressives and antipsychotics in dementia are in accordance with th...Continue Reading

References

Feb 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·M RothR Amrein
Nov 23, 2000·Neurology·L TeriUNKNOWN Alzheimer's Disease Cooperative Study
Apr 28, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eric Wooltorton
Jan 26, 2005·BMJ : British Medical Journal·Sudeep S GillMuhammad Mamdani
Nov 29, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Philippe H RobertBruno Vellas
Mar 1, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Lon S SchneiderPhilip S Insel
Aug 2, 2006·International Psychogeriatrics·Jonathan RabinowitzHenry Brodaty
May 16, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sarah ThompsonKrista L Lanctôt
Sep 12, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Bruce G PollockKimberly A Huber
Nov 3, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jacobo E MintzerAndy Forbes
May 31, 2008·Journal of the American Geriatrics Society·Marci L ChewGeorges Gharabawi
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·George M SavvaUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Jun 26, 2009·Expert Opinion on Drug Safety·Iacopo CancelliMariarosaria Valente
Jul 29, 2009·Archives of Internal Medicine·Isabelle CarrièreMarie-Laure Ancelin
Nov 26, 2009·Archives of Internal Medicine·John C WoolcottCarlo A Marra
Jan 21, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Paul B RosenbergUNKNOWN DIADS-2 Research Group
Mar 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Emilio SacchettiPaolo Valsecchi
Apr 2, 2011·Journal of the American Geriatrics Society·J Craig Nelson, Davangere P Devanand
May 17, 2011·The American Journal of Psychiatry·Cheryl L P VigenLon S Schneider
Aug 4, 2011·BMJ : British Medical Journal·Carol CouplandJulia Hippisley-Cox
Sep 20, 2011·Current Opinion in Psychiatry·Daniela EnacheDag Aarsland
Dec 24, 2011·The American Journal of Psychiatry·Helen C KalesFrederic C Blow
Oct 13, 2012·The Journal of Clinical Psychiatry·Jiska Cohen-MansfieldLaurence Freedman
Oct 19, 2012·The New England Journal of Medicine·D P DevanandBruce Levin
Jul 31, 2013·The American Journal of Psychiatry·Oscar L LopezWilliam E Klunk
Aug 10, 2013·The British Journal of Psychiatry : the Journal of Mental Science·T GerhardS Crystal
Sep 11, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ellen Melbye LangballeGeir Selbæk
Feb 20, 2014·JAMA : the Journal of the American Medical Association·Anton P PorsteinssonUNKNOWN CitAD Research Group

❮ Previous
Next ❯

Citations

Dec 3, 2015·Der Nervenarzt·R HaussmannM Donix

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here