PMID: 44462Jan 1, 1979

Therapy of extrapyramidal motor disturbances by tiaprid (author's transl)

Archiv für Psychiatrie und Nervenkrankheiten
D Claus, J C Aschoff

Abstract

In animal experiments Costall and Naylor (1977) showed that Tiaprid, a benzamide derivative of the orthopamids, inhibits dopamine receptors in the caudate nucleus and putamen but not in the mesolimbic system. Involuntary movements in patients with extrapyramidal movement disorders were reduced by 300 mg daily. Good results were obtained in 56% of 93 patients (25 in this study and 68 from the literature). On the whole the efficacy of Tiaprid seems far better than that of neuroleptics, and side effects are definitely fewer.

Related Concepts

Lenticulostriate Disorders
Benzamides
Dyskinesia, Medication-Induced
Etat Marbre
Dopamine Receptor
Tiapamil
Antipsychotic Effect

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