PMID: 9173207Mar 15, 1997Paper

Therapy of hepatitis C

Medizinische Klinik
D M Alscher, J C Bode

Abstract

The purpose of this review is an update of the therapy of hepatitis C especially with Interferon-alpha. From the large number of publications on this topic the established facts were worked out. Taking these facts as a base guidelines for the therapy in practical use were defined. In addition the aspects of therapeutic strategies of chronic hepatitis C which until now can not definitely be judged are discussed. In the relatively few patients in whom hepatitis C is diagnosed already in the acute phase, Interferon-alpha-treatment (3 x 3 million units 3 times a week) for 3 to 4 months increases the percentage of patients in whom HCV-RNA in the serum is eliminated. In patients with chronic hepatitis C, after decision finding for treatment, a standard scheme is recommended which consists of a monotherapy with recombinant Interferon-alpha. The dosage of Interferon-alpha is in the first 12 to 16 weeks 5 up to 6 million units given 3 times a week. For the further therapy 3 million units 3 times a week seems to be appropriate. The recommended duration of Interferon-alpha-therapy is 12 months. A long-term benefit of about 20% can be achieved in unselected groups of patients when judged on the permanent normalisation of serum transaminase...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OkadaS Mishiro
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Sáez-RoyuelaV Carreño
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarcellinJ P Benhamou
Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Nov 30, 1989·The New England Journal of Medicine·A M Di BisceglieJ H Hoofnagle
Dec 18, 1986·The New England Journal of Medicine·J H HoofnagleE A Jones
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G DiodatiC Davite
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P LamperticoM Colombo
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O ReichardO Weiland
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TakanoM Omata
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y KanazawaT Kamada
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Simmonds
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ShindoT Okuno
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Martinot-PeignouxV Milotova
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G YamadaJ A Kolberg
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H F LöhrG Gerken
Jul 1, 1995·Journal of Vascular Surgery·A V Alexandrov, P M Pullicino
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NaitoT Kamada
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L ChemelloP Pontisso
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·R L CommissarisR J Kleinsorge
Oct 15, 1995·Annals of Internal Medicine·S C Gumber, S Chopra
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KasaharaY Kishida

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Citations

Sep 21, 2000·Pharmaceutical Science & Technology Today·D Bradley
Sep 7, 2006·Epidemiology and Infection·U GungabissoonM E Ramsay

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