Therapy of isolated calf muscle vein thrombosis: a randomized, controlled study

Journal of Vascular Surgery
Thomas SchwarzS M Schellong

Abstract

Treatment of isolated calf muscle vein thrombosis (ICMVT) is controversial. There are no data from prospective, controlled studies. Objective of this article was to compare the efficacy and safety of a short-term course of anticoagulation with compression therapy alone. We prospectively randomized patients with symptomatic, sonographically proven ICMVT in the soleal and/or gastrocnemial muscle veins in two treatment arms. The first received low-molecular-weight heparin for 10 days at therapeutic dosage (nadroparin 180 anti-activated factor X units once daily) and compression therapy for three months, and the second received compression therapy alone. Primary efficacy endpoint of the study was sonographically proven progression of ICMVT into the deep veins and clinical pulmonary embolism (PE) as confirmed by objective testing. Secondary efficacy and primary safety endpoints were major bleeding, death not due to PE, and complete sonographically proven recanalization of the muscle vein. We assessed transient and permanent risk factors for venous thromboembolism. One-hundred seven patients were finally ruled eligible for evaluation: 89% outpatients, 11% hospitalized patients. In the heparin group (n=54) progression to deep vein thr...Continue Reading

References

Sep 1, 1971·The British Journal of Radiology·A N NicolaidesJ T Renney
Jul 1, 1995·The American Journal of Medicine·G R SimonsS Z Goldhaber
Jul 31, 1998·Journal of Vascular Surgery·E M MasudaD T Sato
Oct 31, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·T SchwarzS M Schellong
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Thomas SchwarzSebastian M Schellong
Mar 6, 2003·Journal of Vascular Surgery·P S MacdonaldD Obrand
Jun 20, 2003·Circulation·Richard H White
Dec 10, 2003·Archives of Internal Medicine·Thomas SchwarzSebastian M Schellong
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·S M Schellong
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·M Righini
Aug 8, 2007·Journal of Vascular Surgery·Jean-Luc GilletFrançois A Allaert

❮ Previous
Next ❯

Citations

Oct 19, 2011·Der Internist·S M Schellong
Dec 18, 2013·Semergen·T Fernández-RodríguezA Rodríguez-Lorenzo
Jun 19, 2012·La Revue de médecine interne·J-P GalanaudI Quéré
Jan 12, 2012·Thrombosis and Haemostasis·Beate LuxembourgEdelgard Lindhoff-Last
Nov 16, 2011·Journal of Thrombosis and Haemostasis : JTH·Gualtiero Palareti, S Schellong
Jan 24, 2014·Journal of Thrombosis and Haemostasis : JTH·J-P GalanaudUNKNOWN OPTIMEV-SFMV investigators
Apr 10, 2016·The British Journal of Surgery·J GarryN Labropoulos
Mar 27, 2015·American Journal of Hematology·Twylla Tassava, Theodore E Warkentin
Mar 20, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Ali ElfandiClifford Sales
Oct 29, 2011·Journal of Vascular Surgery·Elna M MasudaQimei He
Jan 30, 2014·Blood·Gualtiero Palareti
Apr 30, 2016·Internal and Emergency Medicine·Angelo PorfidiaRaffaele Landolfi
May 26, 2016·Current Atherosclerosis Reports·Gualtiero Palareti, Michelangelo Sartori
Jun 24, 2015·Emergency Medicine Journal : EMJ·Daniel HornerRichard Body
Sep 12, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M SartoriB Cosmi
Apr 10, 2014·Thrombosis Research·Michelangelo SartoriBenilde Cosmi
Mar 21, 2017·Journal of Thrombosis and Haemostasis : JTH·L FrancoC Becattini
Jul 17, 2014·Vascular and Endovascular Surgery·Jon C Henry, Bhagwan Satiani
Mar 23, 2013·Vascular·Michael J AnstadtRoss Milner
Jun 24, 2017·Journal of Thrombosis and Haemostasis : JTH·F DentaliM Di Nisio
Apr 22, 2017·Emergency Medicine Journal : EMJ·Tom Jones, Dan Horner
Mar 9, 2018·Annals of Vascular Diseases·Sadaaki HoriguchiNozomu Shirasugi
Jan 13, 2018·VASA. Zeitschrift für Gefässkrankheiten·Minna Voigtlaender, Florian Langer
Jun 19, 2012·Journal of the Korean Surgical Society·Woo-Sung YunSeung Huh
Dec 10, 2017·Hematology·Helia Robert-Ebadi, Marc Righini
Apr 27, 2019·Skeletal Radiology·David P DuncanBrady K Huang
Aug 6, 2017·Pediatric Radiology·Rachelle Goldfisher
Aug 13, 2011·Current Opinion in Pulmonary Medicine·Jean-Philippe GalanaudIsabelle Quéré
Apr 10, 2020·The Cochrane Database of Systematic Reviews·George KirkilesisKyriaki Kakavia
May 5, 2020·VASA. Zeitschrift für Gefässkrankheiten·Giovanna ElmiLeonardo Aluigi
Aug 21, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunichiro FujiokaKagami Miyaji
Aug 23, 2020·Thrombosis and Haemostasis·Wiktoria KuczmikRobert D McBane
Jan 17, 2020·Annals of Vascular Diseases·Nobuhiro ShimabukuroMunetaka Masuda
Feb 6, 2015·Medicine·Hiroyuki TominagaSetsuro Komiya
May 31, 2017·Critical Care Nursing Quarterly·Mouhib NaddourOmer Bajwa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.