Therapy of leptomeningeal metastasis in solid tumors

Cancer Treatment Reviews
F MackM Glas

Abstract

Leptomeningeal metastasis (LM), i.e. the seeding of tumor cells to the cerebrospinal fluid (CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various solid tumors. Clinical signs and symptoms may include cranial nerve palsies, radicular symptoms, signs of increased intracranial pressure such as headache, nausea and vomiting, and cognitive dysfunction. In cases of suspected LM, the highest diagnostic sensitivity is provided by the combination of CSF cytology and contrast-enhanced MRI (cranial as well as complete spine). The therapeutic spectrum includes radiotherapy of the clinically involved region as well as systemic and intrathecal chemotherapy. The choice of treatment modalities depends on the type of LM (non-adherent tumor cells in the CSF vs. nodular contrast-enhancing tumor growth), additional systemic involvement (uncontrolled vs. controlled systemic disease) and additional involvement of the CNS parenchyma (LM as the only CNS involvement vs. LM+parenchymal CNS metastases). Larger contrast-enhancing nodular LM or symptomatic lesions of the spine may be treated with radiotherapy. In case of uncontrolled systemic disease, the treatment regimen should include systemic chemotherapy. The choic...Continue Reading

References

Jul 1, 1978·Cancer·H Y YapG R Blumenschein
Jul 24, 1975·The New England Journal of Medicine·W R ShapiroB M Mehta
Feb 1, 1989·European Journal of Cancer & Clinical Oncology·P E PostmusD T Sleijfer
Dec 1, 1980·Annals of Neurology·W A YungW R Shapiro
Jul 1, 1981·The American Journal of Medicine·R S AroneyJ A Levi
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·R D KortmannM Bamberg
May 1, 1994·Archives of Neurology·R GrantL Junck
Sep 1, 2004·Journal of the Neurological Sciences·Ulrich HerrlingerMichael Weller
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W BoogerdCh J Vecht
Jan 8, 2005·Seminars in Neurology·Marc C Chamberlain
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M BlaneyDavid G Poplack
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc C Chamberlain
Sep 5, 2006·Critical Reviews in Oncology/hematology·Andrea Pace, Alessandra Fabi
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David M JackmanBruce E Johnson
Oct 24, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David C GammonMichael J Glantz
Oct 3, 2007·Cancer Chemotherapy and Pharmacology·Ronald J BernardiSusan M Blaney
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nirav Dhruva, Mark A Socinski
Sep 17, 2009·Seminars in Oncology·William R ShapiroWillem Boogerd
Nov 27, 2010·Neurosurgery Clinics of North America·Morris D Groves
Sep 1, 1996·International Journal of Oncology·M Chamberlain, P Kormanik

❮ Previous
Next ❯

Citations

Sep 7, 2016·International Journal of Molecular Sciences·Thomas C ChenAxel H Schönthal
Jun 28, 2016·Palliative & Supportive Care·Michel ReichEmilie Le Rhun
Oct 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEdward S Kim
Jul 18, 2018·The Oncologist·Kaylyn D SinicropePriscilla K Brastianos
Oct 27, 2017·Oncotarget·Gautam NayarPeter E Fecci
Jun 28, 2020·Neuro-oncology·T Jonathan YangElena Pentsova
Oct 19, 2016·Journal of Neuroscience Research·Vahan MartirosianJosh Neman
Feb 6, 2017·Current Treatment Options in Neurology·AnnaCarin HorneGritta Janka
Apr 8, 2020·Case Reports in Oncological Medicine·Nan ChenAihua Edward Yen
Aug 25, 2018·Frontiers in Oncology·Ana TurkajSilvia Novello
Oct 24, 2017·CNS Oncology·Bénédicte DurandEmilie Le Rhun
Feb 9, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Andrey A VolkovFrank D Vrionis
Sep 16, 2017·Journal of Gastrointestinal Cancer·Talal H KhanGregory S Long
Feb 15, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Catherine A O'ConnorEileen M O'Reilly
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Arian Lasocki, Lauren J Caspersz
Jan 23, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·E García Molina, M Penas-Prado
Apr 1, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eleftheria ChortiLisa Zimmer
Jun 18, 2021·British Journal of Neurosurgery·Giovanni PennisiFabio Papacci
Jul 27, 2021·Journal of Clinical Pharmacy and Therapeutics·Ding LiWenzhou Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.