Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block?

Intensive Care Medicine
G EiblT Foitzik

Abstract

To compare the effect of different vasoactive mediator antagonists in the same model of severe acute pancreatitis (AP) and to evaluate whether combinations of the agents exhibit synergistic effects. Prospective experimental study. Microcirculation and pancreas research laboratory at an university hospital. Hundred eighty anesthetized male Sprague-Dawley rats. Six hours after inducing AP by intra-ductal bile salt infusion and i.v. cerulein in 168 rats, these were randomized for therapy with (1) saline, (2) endothelin receptor antagonist (ET-RA), (3) platelet activating factor receptor antagonist (PAF-RA), (4) intercellular adhesion molecule-1 antibody (ICAM-1-AB) or different combinations (5-7). After 24 h the animals underwent a second laparotomy for intra-vital microscopic determination of pancreatic and colonic capillary permeability, blood flow and leukocyte-endothelial interaction. AP induction decreased capillary blood flow and increased permeability and leukocyte rolling. ET-RA, PAF-RA and ICAM-1-AB decreased capillary permeability, increased blood flow and reduced leukocyte rolling. ET-RA was most effective in decreasing capillary permeability in both organs as well as in increasing pancreatic capillary blood flow. Combi...Continue Reading

Citations

Aug 29, 2003·The Journal of Surgical Research·Magnus JohanssonLeif Jansson
May 16, 2003·Vascular Pharmacology·Geerten P van Nieuw Amerongen, Victor W M van Hinsbergh
Aug 9, 2003·Critical Care Medicine·Rhonda S FishelAdrian Barbul
Jun 24, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Brigitte Vollmar, Michael D Menger
Jul 11, 2013·World Journal of Gastroenterology : WJG·Shi-Hai XiaWei Xu
Jul 27, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Guru Trikudanathan, Santhi Swaroop Vege
May 20, 2015·Expert Review of Gastroenterology & Hepatology·Vikesh K SinghEnrique de-Madaria
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kim Hue SuChristopher Christophi
Jul 1, 2008·Microvascular Research·Dirk UhlmannHelmut Witzigmann
Jul 4, 2006·ANZ Journal of Surgery·Christine M Cuthbertson, Christopher Christophi
Apr 12, 2006·The British Journal of Surgery·C M Cuthbertson, C Christophi
Dec 21, 2005·Basic & Clinical Pharmacology & Toxicology·Peter FelderbauerWolfgang E Schmidt
Oct 18, 2005·American Journal of Surgery·Tamara L BerezinaGeorge W Machiedo
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jan W DlugoszEugeniusz Wroblewski
Sep 10, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mariola Sliwińska-MossońHalina Milnerowicz
Jul 8, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M SarucA Huseyinov
Feb 21, 2006·World Journal of Gastroenterology : WJG·Li-Rong Liu, Shi-Hai Xia
Jan 18, 2003·World Journal of Gastroenterology : WJG·En-Qiang MaoSheng-Dao Zhang
Apr 28, 2004·World Journal of Gastroenterology : WJG·Zi-Fa WangCheng-En Pan
Jan 18, 2003·World Journal of Gastroenterology : WJG·Hua ZhaoPei-Yun Li

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