PMID: 6403649Mar 1, 1983Paper

Therapy of murine leukemia with monoclonal antibody against a normal differentiation antigen

The Journal of Experimental Medicine
C C Badger, I D Bernstein

Abstract

The ability of monoclonal antibodies against the Thy-1.1 differentiation antigen to inhibit the growth of transplanted syngeneic AKR/J SL2 leukemic cells has been previously demonstrated. In the present study we further examined therapy with monoclonal antibody of the IgG2a isotype, which was the most effective isotype studied. Intravenous infusion of ascites fluid containing the anti-Thy-1.1 monoclonal antibody 19-E12 1-2 h after tumor implantation led to inhibition of the growth of 3 X 10(5) but not 3 X 10(6) syngeneic SL2 leukemic cells. The achievement of the maximal therapeutic effect required the infusion of a dose containing 3.2 mg of antibody, which inhibited the growth of a subcutaneous inoculum of 3 X 10(5) SL2 leukemic cells in 83% of treated mice. Multiple doses of antibody were no more effective than a single dose given shortly after tumor implantation. The infusion of this relatively large 3.2-mg dose of antibody was required to infiltrate the subcutaneous space and saturate surface Thy-1.1 sites on leukemic cells in a subcutaneous tumor nodule. The failure of antibody to inhibit larger numbers of tumor cells was investigated. Growth of a subcutaneous tumor nodule in mice challenged with more than 3 X 10(5) cells ...Continue Reading

References

Sep 1, 1977·Virology·R C NowinskiR Pickering
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K A KrolickE S Vitetta

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Citations

Mar 15, 1984·Biochemical Pharmacology·I S TrowbridgeC Sauvage
Nov 1, 1987·Annales De L'Institut Pasteur. Immunology·L Edelman
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·G DeNardoC Meares
Jul 15, 1986·Cancer·C C Badger, I D Bernstein
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·D BerendsN J de Both
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·M ColombattiG Tridente
Jun 1, 1992·Immunology and Cell Biology·D QiuD C Jackson
May 10, 1991·International Journal of Cancer. Journal International Du Cancer·C JohanssonL Lindholm

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