Therapy of osteoporosis: calcium, vitamin D, and exercise

The American Journal of the Medical Sciences
I R Reid

Abstract

Calcium supplementation has long been regarded as a fundamental part of the prevention and treatment of postmenopausal osteoporosis, but it is only in recent years that clear evidence has emerged demonstrating its impact on bone mass. Calcium supplementation does not completely arrest postmenopausal bone loss but slows the rate of decline by 30 to 50%. The effect of calcium supplementation on fracture incidence in postmenopausal women has not been established. Vitamin D deficiency is common in the frail elderly, particularly in countries where fortification or food with this vitamin is not practiced. Treatment of vitamin D deficiency has been associated with significant reductions in the number of hip fractures. The role of the potent vitamin D metabolites, calcitriol and alphacalcidol, in the management of postmenopausal osteoporosis is not clear. Although some studies show substantial benefits in bone density or fracture rate from the use of these compounds, the published data are inconsistent. In general, hormone replacement therapy and the potent bisphosphonates produce greater effects on bone density and there is a greater consistency among the results of the published studies of these other interventions. Controlled trial...Continue Reading

References

Aug 1, 1992·Calcified Tissue International·R J HeikinheimoS A Rajala
Sep 27, 1990·The New England Journal of Medicine·B Dawson-HughesS Tannenbaum
Feb 15, 1989·Annals of Internal Medicine·S M Ott, C H Chesnut
Jun 1, 1988·Annals of Internal Medicine·G P DalskyS J Birge
Jan 22, 1987·The New England Journal of Medicine·B RiisC Christiansen

❮ Previous
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Citations

Aug 22, 2007·Biological Trace Element Research·Mehmet Fatih Altan
May 31, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A GreyI R Reid
Jun 11, 1999·Journal of the American Dietetic Association·S G Affenito, J Kerstetter
Jul 16, 1999·Journal of the American Dietetic Association·R C KlesgesH A Lando
Apr 9, 2005·Southern Medical Journal·Julie McKee, Sara L Warber
Aug 5, 2008·Clinical Obstetrics and Gynecology·Allison R Hagey, Michelle P Warren
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Lan-Juan ZhaoHong-Wen Deng
Jan 23, 1999·Pharmacotherapy·M B O'Connell
Jul 28, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Silvia MigliaccioAndrea Lenzi
Sep 22, 2005·Current Rheumatology Reports·Roland Staud
Jun 10, 2000·American Journal of Public Health·N de JongW A van Staveren
Jul 10, 2010·The Journal of Nutrition, Health & Aging·M Ruiz-RamosV M Mendoza-Nunez
Sep 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lan-Juan ZhaoHong-Wen Deng
Oct 26, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Masaki NakaneJ Ruth Wu-Wong
Aug 3, 2018·Journal of the International Society of Sports Nutrition·Chad M KerksickRichard B Kreider
Aug 6, 1999·Obstetrical & Gynecological Survey·N B Watts

❮ Previous
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