PMID: 9545847Apr 18, 1998Paper

Therapy of viral hepatitis

Therapeutische Umschau. Revue thérapeutique
E G Rambusch, M P Manns

Abstract

The therapy of viral hepatitis has great medical and socioeconomic impact. Today chronic viral hepatitis is the most important cause for chronic liver disease, liver cirrhosis, and hepatocellular carcinoma. Hepatitis A and E cause acute courses exclusively whereas infection with the hepatitis B, C, and D virus might result in chronic hepatitis as well. The goal of therapy of chronic viral hepatitis has to be a reduction/normalisation of elevated transaminases, decrease of the serologic parameters of active viral replication, improvement of histology and prevention of complications of chronic hepatitis. The only drug with proven benefit in the treatment of chronic viral hepatitis is interferon alpha. This therapy results in a sustained response in 25 to 40% for hepatitis B and 10 to 25% for hepatitis C infection. New developments under clinical evaluation are Lamivudine and Famciclovir in the treatment of HBV-infection and Ribavirin in combination with INFa for chronic HCV-infection.

Citations

Feb 6, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PerassoG C Icardi
Oct 12, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Dinesh JothimaniHari Conjeevaram
Apr 28, 2005·Developmental and Comparative Immunology·Sonja KothlowUrsula Schultz
Dec 22, 1999·Journal of Virological Methods·R JardiJ Guardia
Jul 2, 1999·Antiviral Research·R P González-PeraltaT L Wright
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiki SuginoshitaTsutomu Chiba
Apr 16, 2003·Health Policy·Isaac D MontoyaDonna D Whitsett
May 17, 2003·European Journal of Medicinal Chemistry·David M AndrewsNaimisha Trivedi
Oct 12, 2001·Journal of Physiology, Paris·A PárUNKNOWN Hungarian Viral Hepatitis Treatment Study Group
Nov 7, 2002·Bioorganic & Medicinal Chemistry Letters·Martin J SlaterEd Robinson
Aug 2, 2000·Journal of Gastroenterology and Hepatology·S Pianko, J G McHutchison
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Mukadder Ayşe SelimogluRaşit Vural Yagci
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T F BaumertT J Liang
Mar 23, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Saad ZakyHeba Mahmoud
Sep 6, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L C HallenS Foser
Sep 1, 2001·Australian and New Zealand Journal of Public Health·E R MillerD R Shaw
Sep 19, 2007·Antimicrobial Agents and Chemotherapy·Anne Marie DoughertyAndrea Cuconati
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·D ColledgeT Shaw
Apr 28, 2001·Journal of Clinical Microbiology·V AlfonsoR H Campos
Jul 20, 2001·Journal of Virology·J Y LeeS Locarnini
Jan 5, 2002·Journal of Addictive Diseases·A RosenblumH Joseph
May 22, 2008·World Journal of Gastroenterology : WJG·Hiroaki OkushinShiro Yuasa

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