Therapy Optimization in Multiple Sclerosis: a cohort study of therapy adherence and risk of relapse

Multiple Sclerosis and Related Disorders
B A CohenHoward Zwibel

Abstract

The objective of the Therapy Optimization in MS (TOP MS) Study was to prospectively assess the relationship between MS disease-modifying therapy (DMT) adherence and MS relapse risk over 2 years. Potential participants were recruited for TOP MS by specialty pharmacies who dispensed glatiramer acetate and beta interferons for MS nationwide. Signed IRB-approved informed consents were returned to the pharmacies. TOP MS used electronic data capture with monthly patient entries. Adherence, measured by medication possession ratio (MPR), was derived from pharmacy shipment records. Logistic regression examined the association between protocol-defined relapses and DMT MPR (<0.5; >0.5-<0.9; >0.9). TOP MS enrolled 3151 persons with MS, and 2410 completed the full 2 years. Across all therapies, the mean MPR for the 2-year completer cohort of 2049 who maintained the same DMT was 0.9+0.2 (range: 0.1-1.0), with 63.8% reaching a 2-year MPR >0.9. Evaluated by categories of MPR, the proportion of participants remaining relapse-free for 24 months increased with increasing MPR, and the proportion with >1 relapses declined with increasing levels of MPR (p<0.0008). Regression analysis revealed the odds of relapse for a patient in the MPR >0.9 MPR gro...Continue Reading

Associated Clinical Trials

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Citations

Jan 5, 2016·Journal of Neurology·Riley BoveD Rintell
Oct 27, 2016·Behavioural Processes·David P JarmolowiczJared M Bruce
Nov 25, 2016·Journal of Managed Care & Specialty Pharmacy·Lucas HigueraSarah Anderson
Jan 11, 2017·Neurodegenerative Disease Management·Barry HendinBrian Werneburg
Aug 25, 2016·Arquivos de neuro-psiquiatria·Caroline Vieira SpessottoYara Dadalti Fragoso
Nov 2, 2016·Therapeutic Advances in Neurological Disorders·Pavan Bhargava, Scott D Newsome
Jul 25, 2017·Health Services Research·Pengxiang LiJalpa A Doshi
Feb 1, 2019·Journal of Pharmacy Practice·Aimee M BanksAutumn D Zuckerman
Jan 15, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu A PichkalevaT P Kalashnikova
Nov 26, 2019·Physiotherapy Canada. Physiothérapie Canada·Kirsten PotterAshley Wooldridge
Dec 21, 2018·International Journal of MS Care·Aliza Ben-ZachariaTracy Walker
Oct 9, 2020·Multiple Sclerosis and Related Disorders·Daniel M HartungDennis N Bourdette
Mar 2, 2021·Therapeutic Advances in Neurological Disorders·Daniel M Hartung
May 6, 2021·Current Neurology and Neuroscience Reports·Daniel M Hartung

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