Therapy optimization of asthenic disorders in remissions in patients with paroxysmal-progressive schizophrenia (a clinical and immunological analysis)

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
S A ZozulyaT P Klyushnik

Abstract

To study the efficacy of the immunomodulatory drug γ-D-glutamyl-L-tryptophan in complex therapy of asthenic disorders in remissions in patients with schizophrenia and to analyze clinical and immunological indicators. Sixty-three male patients (aged 41.9±9.46 years) with paroxysmal-progressive schizophrenia in remission (ICD-10 F20.x1; F20.x2), including 24 patients with affective-asthenic and 39 with negative-asthenic types, were studied. The assessment of the patients' condition was carried out using PANSS, SANS, CDSS, MFI-20. The activity of inflammatory markers: leukocyte elastase (LE) and α1-proteinase inhibitor (a1-PI) was determined in blood serum. The clinical and immunological assessment was performed before, after therapy (in 5 days) and at the remote stage (in a month). Augmentation of standard therapy with γ-D-glutamyl-L-tryptophan facilitated positive reduction in the main clinical manifestations of endogenous asthenia of both types in comparison with placebo (p<0.02). The features of the protease inhibitor system revealed in the patients confirm their clinical heterogeneity and also determine varying efficacy of augmentation by the immunotropic medicine. For patients with the low level of protease activity, which i...Continue Reading

References

Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Benjamin H NatelsonNicholas M Ponzio
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Dec 30, 2008·Brain, Behavior, and Immunity·Charles L RaisonWilliam C Reeves
Aug 3, 2012·Psychotherapy and Psychosomatics·John M KelleyMaurizio Fava
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jose G MontoyaMark M Davis
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anthony L Komaroff
Apr 11, 2018·Autoimmunity Reviews·Franziska SotznyUNKNOWN European Network on ME/CFS (EUROMENE)
Apr 14, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V YakimetsT P Klyushnik

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