Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Heath D Worcester, Mohammad A Vasef

Abstract

Intensified chemotherapy is one of the strategies currently used in the treatment of children with metastatic Ewing sarcoma. However, the increasing dose intensity has not significantly improved the event-free survival. We report a patient who initially presented with localized Ewing sarcoma and later developed metastatic disease that required dose-intensified chemotherapy. The patient's Ewing sarcoma remained refractory to treatment despite continuous intensified chemotherapy and was complicated by a therapy-related acute myeloid leukemia with 11q23 abnormality. Examination of bone marrow at the last clinical follow up demonstrated both acute myeloid leukemia and residual metastatic Ewing sarcoma.

References

Jul 28, 1977·The New England Journal of Medicine·R R ReimerR C Young
Apr 1, 1979·Cancer·K FoucarR D Brunning
Dec 8, 1977·The New England Journal of Medicine·C N ColemanH S Kaplan
Jan 31, 2008·Leukemia & Lymphoma·Vicent Guillem, Mar Tormo

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Methods Mentioned

BETA
amputation
bone
biopsy
MDS

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