Therapy-related hematologic neoplasias after breast cancer. Epidemiologic, etiologic and cytogenetic aspects and new risk factors according to published data and own results

Medizinische Klinik
Detlef HaaseThomas Schulz

Abstract

Breast cancer is the most frequent solid tumor in women. The incidence is increasing. In Germany, about 45,000 women are newly diagnosed each year. The general strategy aims for the best local control of the tumor by surgery and radiotherapy. This strategy is supplemented by systemic adjuvant chemotherapy and/or anti-hormonal therapy. The following substances have shown their efficacy in clinical trials: alkylating agents, antimetabolites, anthracyclines, topoisomerase inhibitors, platinum derivatives, and taxanes. Due to intensified treatment schedules remission rates and overall survival could be significantly improved. On the other hand, the long-term toxicity of this antineoplastic therapy is an increasing problem. Therapy-associated secondary leukemias frequently occur after treatment for malignant lymphomas and multiple myelomas. However, they can also be observed after antineoplastic therapy of solid tumors such as cancers of the breast, lung, testicles and ovaries and sarcomas. The highest risk for secondary leukemias has been attributed to concurrent radiochemotherapy. Therapy-associated hematologic neoplasias are a severe medical problem due to the high incidence of breast cancer and the dismal outcome of secondary le...Continue Reading

Citations

Sep 6, 2008·Diagnostic Cytopathology·Mirjana Marković-GlamocakBoris Labar
Jan 5, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A AmeijideJ Galceran

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