Therapy strategies in vitamin D deficiency with or without rickets: efficiency of low-dose stoss therapy

Journal of Pediatric Endocrinology & Metabolism : JPEM
Torun EmelOktem Faruk

Abstract

Vitamin D deficiency can be treated with daily vitamin D supplementation for several weeks or single-day high-dose vitamin D therapy (stoss therapy). However, there are few studies comparing efficiency and side effects of these two treatment models. We aimed to compare the efficiency and side effects of low-dose stoss therapy and lower-dose daily vitamin D supplementation in children with vitamin D deficiency. Our subjects were 42 patients with ages between 5 months and 3 years with diagnosed vitamin D deficiency. All children had 25-hydroxyvitamin D level lower than 20 ng/mL. Serum biochemical markers and spot urine calcium/creatinine (Ca/Cr) ratio were measured before and after the therapy. Twenty-one patients were treated with stoss therapy (150,000 U/single-dose oral vitamin D3), and 21 patients were treated with daily high-dose vitamin D3 therapy (2000 U/day vitamin D, 6 weeks). Renal ultrasound was performed for both groups of patients after 1 month. Biochemical parameters and Ca/Cr ratio at the end of therapy did not differ in each groups. However, vitamin D levels at the end of stoss therapy were significantly increased compared with daily lower-dose vitamin D therapy group (p<0.001). Nephrocalcinosis or renal stone was...Continue Reading

Citations

Oct 27, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Brynn E Marks, Daniel A Doyle
Sep 28, 2016·Journal of Paediatrics and Child Health·Julie HuynhChristine P Rodda
Sep 16, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Victoria J StokesRajesh V Thakker
Nov 9, 2016·The Cochrane Database of Systematic Reviews·Mohammad Y YakoobZulfiqar A Bhutta
May 29, 2019·Journal of Paediatrics and Child Health·Paul TannousCraig Munns
Feb 26, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Meenakshi BothraVandana Jain
Jan 31, 2015·Nutrition Bulletin·A Spiro, J L Buttriss
May 16, 2014·Indian Pediatrics·John M Pettifor
Aug 7, 2018·EFSA Journal·UNKNOWN EFSA Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA Panel)Monika Neuhäuser-Berthold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Intensive Care Medicine
Constance RippelLara S Shekerdemian
The New England Journal of Medicine
Paul LeeJacqueline R Center
© 2021 Meta ULC. All rights reserved