PMID: 8448565Feb 1, 1993Paper

Therapy with 125I-labelled internalized and non-internalized monoclonal antibodies in nude mice with human colon carcinoma xenografts

Nuclear Medicine and Biology
E F AronssonL O Hafström

Abstract

The therapeutic effects of 125I-labelled (18-97 MBq) monoclonal antibodies (MAb) C-242, C-215 and S-S.1 were studied in nude mice with human colorectal adenocarcinoma tumours. The antibodies were administered 2 or 10-16 days after implantation of the tumour cells. The monoclonal antibody C-242 was internalized into the tumour cells, C-215 was internalized to a lower degree while S-S.1 (unspecific MAb) was not internalized at all. No enhanced therapeutic effect of 125I-C-242 was observed, as a result of Auger electrons, compared with 125I-C-215 and 125I-S-S.1.

References

May 10, 1991·International Journal of Cancer. Journal International Du Cancer·C JohanssonL Lindholm
Jul 1, 1989·Physics in Medicine and Biology·A R Younis, D E Watt
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J S StewartH E Lambert
Dec 15, 1988·International Journal of Cancer. Journal International Du Cancer·L N LarsonJ Holmgren
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D Herlyn, H Koprowski
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G CarlssonL Hafström

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Citations

Jun 25, 2013·Cancer Biotherapy & Radiopharmaceuticals·Johan SpetzEva Forssell-Aronsson
Oct 1, 1996·Physics in Medicine and Biology·J A O'Donoghue, T E Wheldon

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