[Therapy with epidermal growth factor receptor inhibitors. Clinical spectrum of cutaneous adverse effects].

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
Peter Arne GerberBernhard Homey

Abstract

Recently, inhibitors of the epidermal growth factor receptor (EGFR), such as erlotinib, gefitinib, cetuximab or panitumumab, have been successfully established in the therapy of a variety of solid tumors. Cutaneous adverse effects are the most frequent side-effects of these so-called targeted cancer drugs and occur in 45-100% of patients. In addition to a characteristic papulo-pustular rash, adverse effects include painful paronychia, xerosis cutis, pruritus, alopecia or alterations of the hair structure. These often stigmatizing side-effects represent a serious threat to the patients' quality of life and compliance and may lead to dose-reduction or even cessation of the antineoplastic therapy. Considering the steadily growing numbers of patients who receive EGFR-targeting therapy, these medicament-associated cutaneous adverse effects are becoming increasingly more important in the routine clinical practice of dermatologists and oncologists.

References

Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jul 18, 2002·Nature Reviews. Drug Discovery·Joshua H Atkins, Leland J Gershell
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Jul 14, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Segaert, E Van Cutsem
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 15, 2005·The New England Journal of Medicine·Daniela S Krause, Richard A Van Etten
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Jun 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sankha S Mitra, Richard Simcock
Jul 18, 2006·Journal of the American Academy of Dermatology·Julia E GravesMichael P Heffernan
Sep 23, 2006·Nature Reviews. Cancer·Mario E Lacouture
Oct 3, 2006·Journal of the American Academy of Dermatology·Anna Liza C AgeroAllan C Halpern
Dec 6, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A WollenbergE Klein
Dec 7, 2006·Journal of the American Academy of Dermatology·Lindy P Fox
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 25, 2007·The Oncologist·Ruthann M GiustiRichard Pazdur
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bret WackerPablo J Cagnoni
Aug 3, 2007·The New England Journal of Medicine·Wilfried BudachBernhard Homey
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter Arne GerberWilfried Budach
Nov 6, 2007·The New England Journal of Medicine·James A Bonner, Kian Ang
Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alon ScopeAllan C Halpern
Feb 9, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Edwin BölkeWilfried Budach
Feb 20, 2008·Clinical Lung Cancer·Tal GrenaderAnthony Goldberg
Mar 14, 2008·The New England Journal of Medicine·Fortunato Ciardiello, Giampaolo Tortora
Mar 14, 2008·The New England Journal of Medicine·Peter Arne Gerber, Bernhard Homey
May 28, 2008·Experimental Dermatology·Andreas WollenbergKerstin Katzer
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter Arne GerberBernhard Homey
Nov 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian GiroWilfried Budach
Mar 18, 2009·Clinical Lung Cancer·Serena RicciardiFilippo de Marinis
May 20, 2009·Targeted Oncology·Tianhong Li, Roman Perez-Soler
Jun 13, 2009·Journal of Cutaneous Pathology·Marinya PongpudpunthLynne J Goldberg
Sep 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Siegfried SegaertSabine Tejpar
Dec 17, 2009·Journal of the National Cancer Institute·R E EilersMario E Lacouture
Jan 27, 2010·Deutsche medizinische Wochenschrift·A WollenbergT Dirschka
Feb 5, 2010·Oncology·Georg Lurje, Heinz-Josef Lenz
Jan 1, 2009·Oncology·Serena Ricciardi, Filippo de Marinis

❮ Previous
Next ❯

Citations

Oct 27, 2011·European Journal of Medical Research·S Akanay-DieselB Homey
Apr 5, 2012·European Journal of Medical Research·Peter Arne GerberBernhard Homey
May 14, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·L M EhmannB Homey
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lars-Oliver KlotzClaus Jacob
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Peter Arne GerberBernhard Homey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
J LübbeP Y Dietrich
The British Journal of Dermatology
K ten FreyhausD Wilsmann-Theis
Translational Research : the Journal of Laboratory and Clinical Medicine
Sheila NguyenArkadiusz Z Dudek
© 2021 Meta ULC. All rights reserved