PMID: 11341101May 9, 2001Paper

Therapy with pulse methylprednisolone and short course pulse cyclophosphamide for diffuse proliferative glomerulonephritis

Lupus
M MoscaS Bombardieri

Abstract

The incidence of renal flares and the long-term outcome in a group of 33 systemic lupus erythematosus (SLE) patients with diffuse proliferative glomerulonephritis (DPGN) treated with pulse steroids and a short course of pulse cyclophosphamide (CYC) are evaluated. Fifteen patients (45%) experienced a flare of renal disease at some time after the discontinuation of the immunosuppressive (IS) therapy; among these half (24%) were 'early' flares occurring shortly after the discontinuation of therapy, and the other half (21%) were 'late' flares occurring more than 2 y after the discontinuation of the treatment. Nine patients (27%) showed a poor renal outcome at the end of follow-up. On multiple regression analysis, a younger age and a high activity index (AI) on renal histology were found to be correlated with the occurrence of renal flares. Our results suggest that the combination of pulse steroids with a short course of pulse CYC (six to nine pulses) is effective in both controlling disease activity and in preventing the occurrence of renal flares in DPGN. However, short term IS therapy might not be sufficient to maintain disease control in younger patients with active lesions on renal histology. Such patients might be candidates t...Continue Reading

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Citations

Nov 25, 2006·Nature Clinical Practice. Nephrology·Cheuk-Chun Szeto, Lai-Shan Tam
Dec 22, 2010·Nature Reviews. Nephrology·Vladimir Tesar, Zdenka Hruskova
Mar 29, 2002·Kidney International·Marta MoscaStefano Bombardieri
Nov 16, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Yiann E ChenUNKNOWN Collaborative Study Group
Dec 10, 2014·Expert Review of Clinical Immunology·Gabriella Moroni, Claudio Ponticelli
Dec 13, 2012·Autoimmunity Reviews·Remco K M A C LuijtenRonald H W M Derksen
May 6, 2016·Journal of Nephrology·Gabriella MoroniClaudio Ponticelli
Mar 1, 2005·Lupus·P I SidiropoulosD T Boumpas
Feb 27, 2018·Autoimmunity·Mariane Dos SantosFrancisco Veríssimo Veronese
Apr 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cecile Grootscholten, Jo H M Berden
Dec 13, 2018·Nature Reviews. Rheumatology·Mariele GattoAndrea Doria
Dec 14, 2018·Clinical Rheumatology·Rudra Prosad GoswamiAlakendu Ghosh
Nov 26, 2020·La Revue de médecine interne·A MathianZ Amoura

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