There is more to life than revascularization: therapeutic targeting of myocardial ischemia/reperfusion injury

Cardiovascular Therapeutics
Robert M Bell, Derek M Yellon

Abstract

Ischemic heart disease is the world's leading cause of death, and while clinical advances have meant improved and more rapid revascularization, there remains a significant element of myocardial death that thus far has not been successfully targeted in clinical practice, namely lethal reperfusion injury. Ischemia-reperfusion injury has been the subject of intense research over the last 40 years and our appreciation of the mechanisms of cellular death and salvage have increased immensely over this time, to the extent that a number of clearly identifiable therapeutic targets can now be subjected to clinical trials, as the basic science translates into potentially effective therapies in patients presenting with acute coronary syndromes. In this review, we aim to provide an overview of current evidence regarding the mechanisms of lethal reperfusion injury and endogenous protection, how cardioprotective pharmacological manipulations have been approached to date, and to indicate where therapies may be targeted in the future.

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Citations

May 9, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Dumbor L NgaageAugustine Tang
Nov 22, 2013·European Heart Journal·Robert M BellDerek M Yellon
Jul 31, 2013·Canadian Journal of Physiology and Pharmacology·Oana M DuicuDanina M Muntean
Mar 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shiao DingJu Mei
Dec 31, 2014·The Canadian Journal of Cardiology·Bernd EbnerRuth H Strasser
Jul 10, 2016·International Journal of Cardiology·Yi LuMei-Xiang Xiang
Apr 14, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Tanuka DattaNabanita S Datta
Feb 23, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Q XuB Liu
Jan 16, 2014·British Journal of Hospital Medicine·Robert M Bell
May 23, 2013·International Journal of Molecular Medicine·Xian-Yue WangWei-Da Zhang
Aug 17, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Simona M CristescuNandor Marczin
Aug 24, 2012·American Journal of Physiology. Renal Physiology·David J SempleAnne-Marie L Seymour
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·Wei SunBin Liu
Apr 8, 2020·Aging and Disease·Yibo YangBin Liu

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