There is no difference in the disease severity of gastro-oesophageal reflux disease between patients infected and not infected with Helicobacter pylori

Alimentary Pharmacology & Therapeutics
C A FalloneD Ross

Abstract

The role of Helicobacter pylori in gastro-oesophageal reflux disease (GERD) is controversial. To compare the severity of GERD in infected vs. non-infected patients, as part of an ongoing randomized controlled trial that examines the impact of H. pylori eradication on GERD-related outcomes. Consecutive GERD patients underwent urea breath testing and completed validated GERD symptom severity, and quality of life questionnaires as well as, 24-h pH-metry. These parameters, as well as demographics and endoscopic findings were assessed in double-blinded fashion and compared between H. pylori-infected and non-infected subjects. Helicobacter pylori-infected GERD patients (n=50) were significantly older and less educated than non-infected patients (n=51). They also used proton pump inhibitors less often but had no difference in symptoms (as measured with both the Spechler's Activity Index and the Gastrointestinal Symptom Rating Scale), quality of life, endoscopic findings or 24-h pH-metry findings. This prospective, double-blind study demonstrates, using excellent GERD quantifying measures including validated symptom severity scores, endoscopy, and 24-h pH-metry, that there exist no clinically significant differences in clinical or labo...Continue Reading

References

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Citations

Jun 10, 2005·Alimentary Pharmacology & Therapeutics·T NakamuraA Terano
Sep 24, 2005·Helicobacter·Limas Kupcinskas, Peter Malfertheiner
May 9, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R Canzi Almada de Souza, José Hermênio Cavalcante Lima
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
May 23, 2014·Current Opinion in Gastroenterology·Arne Kandulski, Peter Malfertheiner

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