Thermal ablation matches sublobar resection outcomes in older patients with early-stage non-small cell lung cancer

Journal of Vascular and Interventional Radiology : JVIR
Sharon W KwanMichael C Brunner

Abstract

To compare survival outcomes of sublobar resection and thermal ablation for early-stage non-small cell lung cancer (NSCLC) in older patients. SEER-Medicare linked data for patients with a diagnosis of lung cancer from 2007-2009 were used. Patients ≥ 65 years old with stage IA or IB NSCLC who were treated with sublobar resection or thermal ablation were identified. Primary outcome was overall survival (OS), and secondary outcome was lung cancer-specific survival (LCSS). Demographic and clinical variables were compared. Unadjusted OS and LCSS curves were estimated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox model. OS and LCSS curves for propensity score matched groups were also compared. The final unmatched study population comprised 1,897 patients. Patients who underwent sublobar resection were significantly younger (P = .006) and significantly less likely to have a comorbidity index > 1 (P = .036), a diagnosis of chronic obstructive pulmonary disease (P = .017), or adjuvant radiation therapy (P < .0001) compared with patients treated with thermal ablation. Unadjusted survival curves of unmatched groups demonstrated significantly better OS (P = .028) and LCSS (P = .0006) in the resection ...Continue Reading

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Citations

Apr 8, 2014·Journal of Vascular and Interventional Radiology : JVIR·Carole A RidgeStephen B Solomon
Jul 6, 2014·BioMed Research International·Takao HirakiSusumu Kanazawa
Apr 16, 2016·The Indian Journal of Radiology & Imaging·Shivank BhatiaNiramol Savaraj
Aug 19, 2014·Journal of Vascular and Interventional Radiology : JVIR·Sharon W KwanMichael C Brunner
Jul 22, 2016·AJR. American Journal of Roentgenology·Sharon W KwanMichael C Brunner
Jun 29, 2017·AJR. American Journal of Roentgenology·Samdeep K MouliRobert J Lewandowski
Dec 30, 2014·Cardiovascular and Interventional Radiology·Hester J SchefferMartijn R Meijerink
May 17, 2019·Journal of Thoracic Imaging·Fereidoun AbtinRobert Suh
Apr 7, 2016·Journal of Thoracic Imaging·Lillian Xiong, Damian E Dupuy
Jul 15, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Luby Sidoff, Damian E Dupuy
Sep 14, 2017·Journal of Cancer Research and Therapeutics·Xia YangMin Meng
Apr 4, 2021·Journal of Vascular and Interventional Radiology : JVIR·Johannes UhligHyun S Kim

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