Thermal analgesic effects from weak, complex magnetic fields and pharmacological interactions

Pharmacology, Biochemistry, and Behavior
L J MartinMichael A Persinger

Abstract

In several experiments, robust analgesia (equivalent to about 4 mg/kg of morphine) in male rats to thermal stimuli following exposures to weak (1 microT) complex magnetic fields was explored. The analgesia occurred when patterns of magnetic fields with burst-firing-like configurations were presented for 30 min once every approximately 4 s. The analgesic effects were intensity dependent. A different frequency-modulated pattern produced analgesia more quickly. The analgesic effects following exposure to the burst-firing magnetic fields were augmented conspicuously by preinjections of morphine (4 mg/kg) or agmatine (10 mg/kg), but blocked by naloxone (1 mg/kg). The results of these experiments suggest that rational design of the temporal structure of weak magnetic fields may be a novel, inexpensive, and reliable technique for elevating thresholds to some classes of painful stimuli.

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Citations

Apr 27, 2013·PloS One·Nirosha J MuruganMichael A Persinger
Mar 17, 2007·The International Journal of Neuroscience·M A Persinger, S A Koren
Mar 17, 2007·The International Journal of Neuroscience·L S St-PierreM A Persinger
Jun 14, 2012·Electromagnetic Biology and Medicine·Ioannis I VerginadisAngelos M Evangelou
May 16, 2012·Perceptual and Motor Skills·Mathew H Gendle, Megan G McGrath
Dec 5, 2012·International Journal of Radiation Biology·Noa GangMichael A Persinger
Mar 22, 2007·Neuroscience and Biobehavioral Reviews·Cristina Del SeppiaMartin Kavaliers
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 13, 2005·The International Journal of Neuroscience·B E McKay, M A Persinger
Aug 8, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Neil M FournierMichael A Persinger
Oct 12, 2018·Bioelectromagnetics·Leonardo MakinistianIgor Belyaev
May 4, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Justyna MaliszewskaJustyna Rogalska

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