PMID: 15348533Sep 7, 2004Paper

Thermal analysis of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels

Journal of Materials Science. Materials in Medicine
J R MeakinR M Aspden

Abstract

The influence of water on the physical properties of a hydrogel is important for understanding natural tissues and in designing synthetic materials to replace them. In this study, poly (2-hydroxyethyl methacrylate) (pHEMA) was used as a model system to understand how water interacts with the polymer of a hydrogel. Thermal analysis methods (thermogravimetric analysis coupled to mass spectrometry and differential scanning calorimetry) were used to determine: (i) the total water content of pHEMA gels; (ii) how this water was lost during heating; (iii) the relationship between water content of the gel and its glass transition temperature; and (iv) the behavior of the water in the gel on cooling. Previous researchers have invoked various models to describe the organization of water in a hydrogel. In this study, the simplest model which could explain all of the results from the different thermal analysis techniques was one which consisted of three classes of water: (i) hydration water in close proximity to the polymer; (ii) interstitial water in regions or cavities surrounded by polymer chains; and (iii) bulk water.

Citations

Jun 18, 2016·Journal of Molecular Modeling·Pavlo DemianenkoFabienne Poncin-Epaillard
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·Yong Wang, Paulette Spencer
Aug 29, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Benjamin Pearson, Daniel M Espino
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Saeed MiraminiLauren E J Thomas-Seale
Jun 25, 2013·ACS Applied Materials & Interfaces·Lukas BaumannLukas J Scherer

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