PMID: 15348564Sep 7, 2004Paper

Thermal and mechanical properties of biodegradable hydrophilic-hydrophobic hydrogels based on dextran and poly (lactic acid)

Journal of Materials Science. Materials in Medicine
Yeli Zhang, Chih-Chang Chu

Abstract

The thermal and mechanical properties of a new family of biodegradable hydrogels made of photocrosslinked dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) were studied. The changes of thermal and mechanical properties of the dex-AI/PDLLAM hydrogels as functions of dex-AI to PDLLAM composition ratio and immersion time in phosphate buffer solution at 37 degrees C were also investigated. Thermal property data showed that the chemical modification, crosslinking, swelling and hydrolytic degradation affected the glass transition and melting temperatures. Based on thermal data, no phase separation was observed in the bicomponent dex-AI/PDLLAM hydrogels. Mechanical property data showed that, by changing the composition ratio, dex-AI/PDLLAM hydrogels having a wide range of dry and swollen compression moduli could be obtained. The moduli of the dex-AI/DPLLAM hydrogels in dry state decreased with an increase in the PDLLAM composition due to the reduction in glass transition temperature of the hydrogels. The loss of mechanical strength in buffer solutions was attributed to the swelling-induced formation of 3D porous network structure in the early stage of immersion and the hydrolytic degra...Continue Reading

Citations

Aug 14, 2020·Advanced Healthcare Materials·Rahul SinghLevent Beker
Feb 10, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Guoming Sun, Chih-Chang Chu

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