Thermal detection thresholds of Aδ- and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin.

PloS One
Maxim ChuryukanovAndré Mouraux

Abstract

Brief high-power laser pulses applied onto the hairy skin of the distal end of a limb generate a double sensation related to the activation of Aδ- and C-fibres, referred to as first and second pain. However, neurophysiological and behavioural responses related to the activation of C-fibres can be studied reliably only if the concomitant activation of Aδ-fibres is avoided. Here, using a novel CO(2) laser stimulator able to deliver constant-temperature heat pulses through a feedback regulation of laser power by an online measurement of skin temperature at target site, combined with an adaptive staircase algorithm using reaction-time to distinguish between responses triggered by Aδ- and C-fibre input, we show that it is possible to estimate robustly and independently the thermal detection thresholds of Aδ-fibres (46.9±1.7°C) and C-fibres (39.8±1.7°C). Furthermore, we show that both thresholds are dependent on the skin temperature preceding and/or surrounding the test stimulus, indicating that the Aδ- and C-fibre afferents triggering the behavioural responses to brief laser pulses behave, at least partially, as detectors of a change in skin temperature rather than as pure level detectors. Most importantly, our results show that the...Continue Reading

References

Apr 2, 1979·Experimental Brain Research·J Moors, A J Vendrik
Sep 1, 1979·Journal of Neurophysiology·I Darian-SmithP Champness
Sep 1, 1979·Journal of Neurophysiology·I Darian-SmithV C Ming
Jan 11, 1976·IEEE Transactions on Bio-medical Engineering·R A MeyerV B Mountcastle
May 10, 1976·Experimental Brain Research·A CarmonJ Goldberg
Jan 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·P Bjerring, L Arendt-Nielsen
Jul 1, 1970·Journal of Comparative and Physiological Psychology·E R AdairJ A Stolwijk
Jan 1, 1984·Experimental Brain Research·B BrommR D Treede
Dec 23, 1983·Neuroscience Letters·B BrommR D Treede
Apr 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·R G HallinZ Wiesenfeld
May 5, 1983·Brain Research·J N Campbell, R H LaMotte
Aug 22, 2000·The Journal of Investigative Dermatology·J L LévêqueC Poelman
Oct 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E OpsommerL Plaghki
Apr 11, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A MourauxL Plaghki
May 24, 2003·Brain Research·Yuan Bo PengRichard H Gracely
Sep 1, 1956·Journal of Applied Physiology·H T HAMMELD MURGATROYD
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Plaghki, A Mouraux
Mar 11, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuT S Jensen
Jun 7, 2005·Pain·Ulf BaumgärtnerRolf-Detlef Treede
Apr 30, 2010·PloS One·Léon PlaghkiDaniel Le Bars

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Citations

Apr 18, 2014·Journal of Cognitive Neuroscience·Elisabeth ColonAndré Mouraux
Nov 6, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ramy E AbdelhamidAlice A Larson
Sep 16, 2015·The European Journal of Neuroscience·Diana M TortaAndré Mouraux
Jun 10, 2015·Pain·Flavia ManciniGian Domenico D Iannetti
Oct 3, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Valéry LegrainAndré Mouraux
Sep 23, 2014·PloS One·Hocine SlimaniRon Kupers
Dec 21, 2016·Scientific Reports·Flavia ManciniGiandomenico D Iannetti
May 11, 2017·Psychological Science·Khatereh BorhaniPatrick Haggard
Nov 27, 2016·The Journal of Pain : Official Journal of the American Pain Society·Nathanial R EckertJoseph L Riley
Feb 19, 2017·Cognition·Brianna BeckPatrick Haggard
Jul 12, 2018·The Journal of Physiology·Cédric LenoirEmanuel N van den Broeke
Mar 14, 2019·Journal of Neurophysiology·Antonio CataldoPatrick Haggard
Sep 18, 2013·Pain·Hocine SlimaniRon Kupers
May 26, 2016·Physics in Medicine and Biology·Jun MotogiYoshihiro Muragaki
Dec 12, 2019·European Journal of Pain : EJP·K S FrahmO K Andersen
Apr 14, 2020·PLoS Biology·Yifei GuoGian Domenico Iannetti
Oct 5, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Segolene LithfousAndre Dufour
Mar 6, 2019·BMC Anesthesiology·Anna Sellgren EngskovJonas Åkeson
Jun 27, 2019·Journal of Neurophysiology·Stuart W G DerbyshireChristopher L Asplund
Jul 6, 2016·The Journal of Physiology·Emanuel N van den BroekeAndré Mouraux
Oct 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Maaike Van Den HouteOmer Van den Bergh
Jun 9, 2020·Frontiers in Pharmacology·Sabien G A van Neerven, André Mouraux
Aug 10, 2020·Brain Imaging and Behavior·Han-Gue JoUte Habel
Oct 17, 2020·European Journal of Pain : EJP·Mark SchnakenbergRoman Rukwied

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