Thermal expansion of the cryoprotectant cocktail DP6 combined with synthetic ice modulators in presence and absence of biological tissues.

Cryobiology
David P EisenbergYoed Rabin

Abstract

This study explores physical effects associated with the application of cryopreservation via vitrification using a class of compounds which are defined here as synthetic ice modulators (SIMs). The general classification of SIMs includes molecules that modulate ice nucleation and growth, or possess properties of stabilizing the amorphous state, by virtue of their chemical structure and at concentrations that are not explained on a purely colligative basis. A sub-category of SIMs, referred to in the literature as synthetic ice blockers (SIBs), are compounds that interact directly with ice nuclei or crystals to modify their structure and/or rate of growth. The current study is part of an ongoing effort to characterize thermo-mechanical effects during vitrification, with emphasis on measuring the physical property of thermal expansion-the driving mechanism to thermo-mechanical stress. Materials under investigation are the cryoprotective agent (CPA) cocktail DP6 in combination with one of the following SIMs: 12% polyethylene glycol 400, 6% 1,3 cyclohexanediol, and 6% 2,3 butanediol. Results are presented for the CPA-SIM cocktail in the absence and presence of bovine muscle and goat artery specimens. This study focuses on the upper p...Continue Reading

References

Jan 1, 1992·Journal of Hematotherapy·S D Rowley
Oct 1, 1986·The British Journal of Ophthalmology·L P FongD E Pegg
Jun 22, 2000·Cryobiology·B WowkG M Fahy
Sep 26, 2006·Medical Engineering & Physics·Paul S SteifYoed Rabin
Sep 11, 2007·Annals of Biomedical Engineering·Jorge L Jimenez RiosYoed Rabin
Jan 11, 2008·Cell Preservation Technology·Paul S SteifYoed Rabin
Apr 17, 2008·Journal of Biomechanical Engineering·Paul S SteifYoed Rabin
Oct 30, 2008·Experimental Mechanics·Jorge L Jimenez Rios, Yoed Rabin
Jan 5, 2010·Organogenesis·Michael J Taylor, Simona Baicu
May 14, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Charles J Hunt

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Citations

Oct 31, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Gregory M FahyGeny M M Groothuis
Jul 29, 2017·Journal of Biomechanical Engineering·Lili E EhrlichYoed Rabin
Nov 26, 2015·Journal of Biomechanical Engineering·David P EisenbergYoed Rabin
Apr 4, 2015·Journal of Biomechanical Engineering·David P Eisenberg, Yoed Rabin
Jun 26, 2021·Journal of Applied Mechanics·Prem K Solanki, Yoed Rabin
Jun 28, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Michael J TaylorSebastian E Giwa

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